{"id":"W4415794328","doi":"10.1161/circ.152.suppl_3.4369873","title":"Abstract 4369873: <i>LPA</i> -Targeted siRNAs Lower Lp(a) by Over 90%: A Meta-Analysis of Olpasiran, Lepodisiran, and Zerlasiran","year":2025,"lang":"en","type":"article","venue":"Circulation","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Calgary","funders":"","keywords":"Adverse effect; Small interfering RNA; Apolipoprotein B; Confidence interval; Clinical trial; Relative risk; Meta-analysis; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01300305,0.002535298,0.01655345,0.002989514,0.000466281,0.003641149,0.001464195,0.002047432,0.004840673],"category_scores_gemma":[0.01667755,0.00102415,0.03176706,0.003352728,0.0006543376,0.00140972,0.001005602,0.002126589,0.000632996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00184082,"about_ca_system_score_gemma":0.001803727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003946183,"about_ca_topic_score_gemma":0.007427399,"domain_scores_codex":[0.9934139,0.003593445,0.001578885,0.0006231618,0.0005953381,0.0001954],"domain_scores_gemma":[0.9916602,0.005592349,0.001507557,0.0002526038,0.0007740332,0.0002132603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.01581908,0.00004882295,0.001590041,0.1645612,0.8036091,0.00009674682,0.00006037666,0.0004216215,0.000807656,0.0001149467,0.001033218,0.01183709],"study_design_scores_gemma":[0.004572031,0.0006519078,0.002943887,0.007470671,0.9823399,0.00005657664,0.00003118368,0.0001748378,0.0001693635,0.0001905349,0.001377895,0.00002116967],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01776263,0.9766798,0.001051828,0.0006904951,0.0004876145,0.0008008662,0.001209087,0.00009180797,0.001225892],"genre_scores_gemma":[0.482601,0.503371,0.003516885,0.003651242,0.0009388006,0.001885824,0.002256026,0.0001389438,0.001640313],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01655345,"threshold_uncertainty_score":0.06876755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02648920046918938,"score_gpt":0.2879977393573365,"score_spread":0.2615085388881471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}