{"id":"W4415803482","doi":"10.1021/acs.orglett.5c04043","title":"Metal-Free, Photoinduced On-DNA Synthesis of β-Hydroxy Sulfides","year":2025,"lang":"en","type":"article","venue":"Organic Letters","topic":"Sulfur-Based Synthesis Techniques","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Pharmacophore; Scope (computer science); Compatibility (geochemistry); Chemical space; Drug discovery; Simplicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002742023,0.0003124735,0.0004951618,0.000241315,0.00007918262,0.00002948691,0.0009453457,0.0001896069,0.002227235],"category_scores_gemma":[0.001511199,0.0003035626,0.000229352,0.000403033,0.0001513895,0.00008818982,0.0001586922,0.0002513306,0.00006445798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002130099,"about_ca_system_score_gemma":0.00009877908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006600464,"about_ca_topic_score_gemma":0.00001022553,"domain_scores_codex":[0.9982819,0.00006079852,0.0004648244,0.0004795372,0.0003517327,0.0003612181],"domain_scores_gemma":[0.9971098,0.001069792,0.0001904153,0.001518962,0.00004516988,0.00006589287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003542255,0.0001221721,0.0003578083,0.0001314004,0.0002077819,0.00001609893,0.00004235073,4.993359e-7,0.9840003,0.0002135524,0.01358991,0.001282661],"study_design_scores_gemma":[0.0002900669,0.00001053882,0.0001386764,0.0002910463,0.0001398697,0.000003071869,0.00006231877,0.000006113114,0.9971794,0.0002583361,0.001362256,0.0002582702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774396,0.00004355236,0.0001157712,0.004397264,0.00008640753,0.0001074519,0.0000356845,0.0003959871,0.01737824],"genre_scores_gemma":[0.9964192,0.00001638538,0.0006945418,0.002402474,0.00004224526,0.00006807907,0.000005478915,0.00006471328,0.000286908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01897953,"threshold_uncertainty_score":0.9999416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00852663290749654,"score_gpt":0.2235529498357806,"score_spread":0.2150263169282841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}