{"id":"W4415805378","doi":"10.1021/jacsau.5c01230","title":"<i>In Vivo</i> Evaluation of Liver Injury and Arthritis Enabled by a Nitroxyl-Activated Near-Infrared Fluorescence and Photoacoustic Dual-Modality Imaging Probe","year":2025,"lang":"en","type":"article","venue":"JACS Au","topic":"Photoacoustic and Ultrasonic Imaging","field":"Engineering","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Bagui Scholars Program of Guangxi Zhuang Autonomous Region; National Natural Science Foundation of China","keywords":"Photoacoustic imaging in biomedicine; Fluorescence; Moiety; Nitric oxide; Absorption (acoustics); Fluorescence-lifetime imaging microscopy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005808688,0.0001719902,0.0002551636,0.0000984169,0.00007463276,0.00005494936,0.00005968262,0.00006052002,0.00004109397],"category_scores_gemma":[0.0001907731,0.0001906521,0.00002166957,0.0002856502,0.0001196606,0.0002758784,0.000044295,0.0001813316,5.311377e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001712784,"about_ca_system_score_gemma":0.0001473376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006543833,"about_ca_topic_score_gemma":0.00002187669,"domain_scores_codex":[0.9988776,0.00006887382,0.0002896975,0.0002500707,0.0002220551,0.0002916526],"domain_scores_gemma":[0.9995092,0.0001167115,0.00004878374,0.0001736282,0.00009554721,0.00005611271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00003745015,0.00003877236,0.002174688,0.0002727337,0.00002841447,0.000007161693,0.0007142751,0.0005965443,0.9836498,0.00002357303,0.001859551,0.01059704],"study_design_scores_gemma":[0.001544492,0.00001574757,0.009067984,0.0004870225,0.00008310345,0.00001393578,0.0001908004,0.7082605,0.278697,0.001106245,0.0002786815,0.0002543954],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926815,0.001734784,0.002909095,0.00005987446,0.0001486788,0.0005369284,0.00010613,0.00008391259,0.001739117],"genre_scores_gemma":[0.9989036,0.0002683836,0.000583308,0.00007631772,0.00001439407,0.00005840013,0.000007038976,0.00001813903,0.0000703785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.707664,"threshold_uncertainty_score":0.7774567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005271063784708011,"score_gpt":0.2249545674569455,"score_spread":0.2196835036722375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}