{"id":"W4415806188","doi":"10.1038/s44319-025-00612-4","title":"Early-stage lung adenocarcinoma affects DNA methylation and gene expression in adjacent tissues","year":2025,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Key Research and Development Program of China; Fundamental Research Funds for the Central Universities; Chinese Society of Clinical Oncology; Fundo para o Desenvolvimento das Ciências e da Tecnologia; Beijing Health Promotion Association","keywords":"DNA methylation; Methylation; CpG site; Adenocarcinoma; Gene expression; Gene; Regulation of gene expression; Gene expression profiling; Lung cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404154,0.0001184009,0.0002724116,0.0004047714,0.0001624637,0.0002858742,0.00008985533,0.0001530274,0.0008217961],"category_scores_gemma":[0.0003529864,0.0001187114,0.0001375665,0.000248781,0.0001517534,0.000131731,0.0001813735,0.0001745194,0.000159813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000144988,"about_ca_system_score_gemma":0.0001357246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001406963,"about_ca_topic_score_gemma":0.002771746,"domain_scores_codex":[0.9998915,0.00002099363,0.000008181162,0.00003296301,0.00002286421,0.00002342723],"domain_scores_gemma":[0.9998477,0.0000454936,0.00004818495,0.00001299836,0.00001701923,0.00002859856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007531318,0.00004046023,0.5288219,0.00005175223,0.00008270497,0.0003631319,0.0001830929,0.0004434497,0.4553876,0.00007093466,0.00006651218,0.01373534],"study_design_scores_gemma":[0.000005765226,0.0001737081,0.9719464,0.000004158057,0.00003467432,0.0005940785,0.0001318745,0.0007150717,0.02592321,0.00009486853,0.0003713392,0.000004852455],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990481,0.0003043214,0.0003254174,0.000009625876,9.579533e-7,0.000003097757,0.0001053953,0.000006504584,0.0001966577],"genre_scores_gemma":[0.9994057,0.0001012655,0.0001669353,0.000007682402,0.000001133007,0.000002935582,0.0001157283,0.000002144786,0.0001963727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001406963,"threshold_uncertainty_score":0.002797544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008118898540272972,"score_gpt":0.2708895293808543,"score_spread":0.2627706308405813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}