{"id":"W4415816079","doi":"10.1038/s41591-025-03955-6","title":"Physical activity as a modifiable risk factor in preclinical Alzheimer’s disease","year":2025,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Toronto Rehabilitation Institute; University of Toronto; Sunnybrook Health Science Centre","funders":"National Center for Research Resources; National Institute on Aging; Massachusetts Life Sciences Center; National Institutes of Health; Centre d'Imagerie BioMédicale; Massachusetts General Hospital; National Institute of Biomedical Imaging and Bioengineering; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital; Doris Duke Charitable Foundation","keywords":"Disease; Cognition; Physical activity; Cognitive decline; Risk factor; Association (psychology); Physical exercise; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004220511,0.0002171446,0.000520769,0.0003097235,0.00006742533,0.00001078853,0.0001477528,0.0002172767,0.0006249307],"category_scores_gemma":[0.002507658,0.0001494561,0.000127134,0.0006756047,0.0002321525,0.00008749916,0.00009957358,0.001936409,0.00006355274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008340173,"about_ca_system_score_gemma":0.0003869227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002429827,"about_ca_topic_score_gemma":0.00001232253,"domain_scores_codex":[0.9979223,0.0001882362,0.0002136256,0.0005111075,0.0007433717,0.000421383],"domain_scores_gemma":[0.9985039,0.000502909,0.00006189047,0.000390543,0.0001657045,0.0003751084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006495662,0.004220256,0.7789533,0.0002701137,0.0005426568,0.0005719569,0.0002833801,0.000005289419,0.004172208,0.001221372,0.009077974,0.1941859],"study_design_scores_gemma":[0.006157865,0.0007309628,0.9752815,0.0005519757,0.0005871198,0.00000340707,0.00006715448,0.002706487,0.004474907,0.001885343,0.007418151,0.000135145],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658775,0.002385363,0.00008645963,0.01121283,0.0002808807,0.0009678178,0.00002459724,0.00006370522,0.01910089],"genre_scores_gemma":[0.9940953,0.0002126815,0.00002837962,0.001326994,0.0004017846,0.00007775858,0.00002537263,0.00001521911,0.003816522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1963282,"threshold_uncertainty_score":0.8412843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03511583692950909,"score_gpt":0.4361392860405374,"score_spread":0.4010234491110283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}