{"id":"W4415816823","doi":"10.1001/jamanetworkopen.2025.40931","title":"Assessment of Adjuvant Endocrine Therapy With Ovarian Function Suppression by Breast Cancer Index","year":2025,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; University of Calgary","funders":"National Cancer Institute; National Health and Medical Research Council; Medical Research Council; ECOG-ACRIN Cancer Research Group; National Institutes of Health; Ipsen; American College of Radiology Imaging Network; NRG Oncology; Pfizer; BioTheranostics; AstraZeneca; Breast Cancer Research Foundation; Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung; Oncosuisse","keywords":"Exemestane; Breast cancer; Adjuvant; Tamoxifen; Endocrine system; Hormone; Adjuvant therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"medium","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002949683,0.0003619582,0.0007062024,0.000311518,0.0001619859,0.0004835975,0.000290894,0.0003616642,0.001668918],"category_scores_gemma":[0.00312334,0.0001547781,0.0007656713,0.0004277252,0.0002637654,0.0004121888,0.0003273636,0.0005779378,0.000207298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003438349,"about_ca_system_score_gemma":0.0004678863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003845272,"about_ca_topic_score_gemma":0.001084705,"domain_scores_codex":[0.9991817,0.0004064364,0.0000810351,0.0001384065,0.0001439569,0.00004839464],"domain_scores_gemma":[0.9980241,0.0004677452,0.0009815221,0.0001733091,0.0001130998,0.0002402309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2514043,0.001221093,0.6449571,0.0007967008,0.002537597,0.00007282591,0.00007511953,0.001525578,0.00541401,0.0003551942,0.00175037,0.08989006],"study_design_scores_gemma":[0.01660012,0.04226434,0.9207422,0.000130489,0.003383918,0.0004077623,0.00006209919,0.004407072,0.004671149,0.000896879,0.006399878,0.00003408784],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868171,0.005055828,0.0009674068,0.0003330247,0.00008794241,0.0006112271,0.002062526,0.0000359656,0.004029043],"genre_scores_gemma":[0.9966286,0.0004090508,0.0006034915,0.0001308272,0.00007869526,0.0002452387,0.001225627,0.000002905945,0.0006755662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002949683,"threshold_uncertainty_score":0.01559961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004230010577444521,"score_gpt":0.2771259045078664,"score_spread":0.2728958939304219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}