{"id":"W4415820230","doi":"10.3390/curroncol32110614","title":"Proteomic Perspectives on KRAS-Driven Cancers and Emerging Therapeutic Approaches","year":2025,"lang":"en","type":"article","venue":"Current Oncology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"KRAS; Proteomics; Acquired resistance; Proteome; Colorectal cancer; Pancreatic cancer; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116792,0.0001191486,0.0001312437,0.00007397441,0.00009871989,0.00001219326,0.00008209448,0.00009854733,0.0000111486],"category_scores_gemma":[0.00003757709,0.0001097729,0.00004632855,0.00007592473,0.0001202372,0.000002279693,0.00006115743,0.0001164508,0.000002299786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007172593,"about_ca_system_score_gemma":0.000168806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003867921,"about_ca_topic_score_gemma":0.00000858852,"domain_scores_codex":[0.999235,0.00009885753,0.000119238,0.0003314057,0.00005204607,0.0001634713],"domain_scores_gemma":[0.9997067,0.00001169859,0.00005535886,0.000151325,0.00003490733,0.00003995042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007474365,0.0004878195,0.007264322,0.0001951964,0.0003016403,0.000004100282,0.001611189,0.001192485,0.3431401,0.0463164,0.001320334,0.597419],"study_design_scores_gemma":[0.005157175,0.002021294,0.0108709,0.0002931875,0.0001681195,0.00002092225,0.004411684,0.007082549,0.2136264,0.002904166,0.7525174,0.0009262011],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719381,0.01556525,0.004172694,0.001206639,0.0003930892,0.000647111,0.000007317734,0.00002787573,0.006041965],"genre_scores_gemma":[0.9985609,0.0006330121,0.00024298,0.0001154911,0.0001415888,0.0001120677,0.00002140188,0.000008626022,0.0001639415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.751197,"threshold_uncertainty_score":0.4476408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0618820775807169,"score_gpt":0.3536056085503817,"score_spread":0.2917235309696648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}