{"id":"W4415827797","doi":"10.1101/2025.11.01.685925","title":"Differential Branched-Chain Amino Acid Metabolism in Tissues of Tumor-Bearing Mice","year":2025,"lang":"","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada; York University","keywords":"Cachexia; Skeletal muscle; Adipose tissue; mTORC1; Amino acid; Metabolism; Amino acid transporter; Transporter; Beta oxidation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003493563,0.0008561907,0.000480678,0.001883209,0.0004853376,0.0007364267,0.0004007127,0.0008748632,0.003521407],"category_scores_gemma":[0.0001678946,0.0005601432,0.0007588041,0.0006526697,0.0007466357,0.0005154408,0.0004408863,0.00194787,0.001077482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000888935,"about_ca_system_score_gemma":0.0005416881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001931603,"about_ca_topic_score_gemma":0.00305795,"domain_scores_codex":[0.999454,0.00004676561,0.00005117408,0.0001869028,0.0001264516,0.0001346932],"domain_scores_gemma":[0.9993089,0.00004511968,0.0002163835,0.00006852249,0.00007625373,0.0002848544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008117597,0.0001410823,0.0005293289,0.00005671583,0.00001959224,0.00008413603,0.0000518052,0.0001377465,0.9968399,0.0001670641,0.0001065839,0.001054371],"study_design_scores_gemma":[0.0001590787,0.00193522,0.01504327,0.00004180197,0.00009345708,0.0005501815,0.0002589199,0.002324091,0.9747917,0.0002318204,0.004535485,0.00003497619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812248,0.001487169,0.006573501,0.0003328988,0.0001250116,0.0001458211,0.006908161,0.0004872216,0.002715362],"genre_scores_gemma":[0.9654282,0.001659803,0.008150685,0.0003383067,0.00003167149,0.0004917997,0.006098677,0.0003649857,0.01743584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003521407,"threshold_uncertainty_score":0.01178032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007924370799235607,"score_gpt":0.219728524640667,"score_spread":0.2118041538414314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}