{"id":"W4415830196","doi":"10.1016/j.jchf.2025.102780","title":"Survodutide for the Treatment of Obesity","year":2025,"lang":"en","type":"article","venue":"JACC Heart Failure","topic":"Pharmacology and Obesity Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Health Canada; Respicardia; Bausch Health; Brigham and Women's Hospital; Irish Research Council; Sanofi; Abiomed; Novo Nordisk; National Institutes of Health; Regeneron Pharmaceuticals; Dexcom; Arrowhead Pharmaceuticals; Amgen; Boehringer Ingelheim; Esperion Therapeutics; Alnylam Pharmaceuticals; Idorsia Pharmaceuticals; University of Toronto; Cytokinetics; McMaster University; Vifor Pharma; York University; Pfizer; Obesity Canada; Science Foundation Ireland; AstraZeneca; Eli Lilly and Company; American Heart Association","keywords":"","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002028736,0.0002265724,0.0004441483,0.0003269531,0.0002207357,0.0002586305,0.0001996869,0.0002651236,0.002383388],"category_scores_gemma":[0.0002030427,0.00005396336,0.0003756621,0.0001915787,0.0001637261,0.0001630292,0.0002048307,0.001434564,0.0003730934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001658151,"about_ca_system_score_gemma":0.0005043157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005693978,"about_ca_topic_score_gemma":0.002506505,"domain_scores_codex":[0.9999225,0.00002341527,0.00000585999,0.00000764542,0.0000237438,0.00001681472],"domain_scores_gemma":[0.9999397,0.00001380388,0.00001696493,0.000002826775,0.000007026485,0.00001973528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005278444,0.001789649,0.003695479,0.001574069,0.0002734338,0.001308976,0.00008719821,0.0002770305,0.03226682,0.003918271,0.01458049,0.9349501],"study_design_scores_gemma":[0.01639032,0.03446159,0.1523234,0.004006545,0.00148852,0.02659072,0.0006226968,0.003319937,0.04342164,0.008551127,0.7086471,0.0001764706],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.2341989,0.6965758,0.003123142,0.01105595,0.002306097,0.0001494942,0.00046813,0.0001951995,0.05192721],"genre_scores_gemma":[0.655647,0.3121044,0.004884437,0.005658353,0.00182397,0.00009257114,0.0004397892,0.00003498625,0.01931438],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002383388,"threshold_uncertainty_score":0.007973194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01919148858859524,"score_gpt":0.337503783135423,"score_spread":0.3183122945468277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}