{"id":"W4415830196","doi":"10.1016/j.jchf.2025.102780","title":"Survodutide for the Treatment of Obesity","year":2025,"lang":"en","type":"article","venue":"JACC Heart Failure","topic":"Pharmacology and Obesity Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Health Canada; Respicardia; Bausch Health; Brigham and Women's Hospital; Irish Research Council; Sanofi; Abiomed; Novo Nordisk; National Institutes of Health; Regeneron Pharmaceuticals; Dexcom; Arrowhead Pharmaceuticals; Amgen; Boehringer Ingelheim; Esperion Therapeutics; Alnylam Pharmaceuticals; Idorsia Pharmaceuticals; University of Toronto; Cytokinetics; McMaster University; Vifor Pharma; York University; Pfizer; Obesity Canada; Science Foundation Ireland; AstraZeneca; Eli Lilly and Company; American Heart Association","keywords":"","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001094265,0.00009459312,0.0002512254,0.00004173768,0.0001243163,0.000003323402,0.00004272594,0.00007225107,0.0001019186],"category_scores_gemma":[0.00002697422,0.00005503964,0.0001681095,0.0001065861,0.00005909666,0.00001685048,0.000009822312,0.00004890314,0.00001837542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008445535,"about_ca_system_score_gemma":0.0001237558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007921729,"about_ca_topic_score_gemma":0.00009566182,"domain_scores_codex":[0.9994845,0.00003174561,0.0001321361,0.0001377852,0.00006207728,0.0001517782],"domain_scores_gemma":[0.9992767,0.0003620629,0.00002351538,0.0002313422,0.00006378188,0.00004262966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001079284,0.004870248,0.6945219,0.0002402762,0.001619466,0.00001845017,0.000604842,0.00001967138,0.0163004,0.002353886,0.267474,0.01089758],"study_design_scores_gemma":[0.00263233,0.0005889073,0.2960645,0.00002462572,0.0004665378,0.000006305138,0.00007544069,0.00007017292,0.05921116,0.0001656223,0.640654,0.00004039683],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9493908,0.001545265,0.000313867,0.0465866,0.0002602112,0.001312168,0.00002704387,0.00003907103,0.0005249883],"genre_scores_gemma":[0.9908966,0.0001514351,0.001635975,0.001208378,0.0000936598,0.0001418765,0.00001528536,0.000005633665,0.005851198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3984574,"threshold_uncertainty_score":0.2244451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01919148858859524,"score_gpt":0.337503783135423,"score_spread":0.3183122945468277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}