{"id":"W4415831778","doi":"10.17615/yvmq-kt94","title":"Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas","year":2025,"lang":"","type":"article","venue":"UNC Libraries","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institute on Minority Health and Health Disparities; National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; Kaiser Foundation Research Institute; Ministério da Saúde; Manchester Biomedical Research Centre; Fundação de Amparo à Pesquisa do Estado de Minas Gerais; NHLBI Division of Intramural Research; Financiadora de Estudos e Projetos; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Hankuk University of Foreign Studies; Canadian Institutes of Health Research; National Institute of Dental and Craniofacial Research; Andrea and Charles Bronfman Philanthropies; University of Washington; University of Minnesota; National Center on Minority Health and Health Disparities; National Institute for Health and Care Research; National Institutes of Health; San Diego State University; National Heart, Lung, and Blood Institute; University of Miami; Northwestern University; Jackson State University; British Heart Foundation; Mississippi State Department of Health; Kidney Research UK; National Cancer Institute; Office of Dietary Supplements; U.S. Department of Health and Human Services","keywords":"Effector; Genome-wide association study; Genetic association; Population; Gene; Kidney disease; Function (biology); Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005954338,0.0003853629,0.0003733695,0.001129588,0.001050384,0.0006825673,0.0003952975,0.0004202101,0.001917817],"category_scores_gemma":[0.001856696,0.0002410541,0.0004958435,0.002410771,0.000354816,0.0002995641,0.0008030001,0.0004634554,0.0001673447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002789097,"about_ca_system_score_gemma":0.0003228025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02918623,"about_ca_topic_score_gemma":0.02156398,"domain_scores_codex":[0.999473,0.0001869123,0.00004215004,0.0001498542,0.00004668059,0.0001013391],"domain_scores_gemma":[0.999193,0.0001742037,0.0002861648,0.0001020853,0.00009078755,0.0001538031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002348406,0.0000252545,0.9970099,0.00001110023,0.0001625094,0.0001428205,0.0002820619,0.00004694643,0.0007211299,0.00007093874,0.0001095452,0.001182942],"study_design_scores_gemma":[0.000008240192,0.00003609067,0.9988627,0.000009777316,0.0001099433,0.000205644,0.0003844225,0.00009466894,0.00007945291,0.00003694393,0.0001687018,0.000003358627],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990275,0.0001592817,0.00008256218,0.00003307513,0.000002649873,0.000003054977,0.0004160401,0.000003147279,0.0002727502],"genre_scores_gemma":[0.9993981,0.0001048623,0.00009354763,0.00001697706,0.000004130794,0.000003725067,0.0002287797,0.00000216512,0.0001476702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02918623,"threshold_uncertainty_score":0.05803269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585146421524289,"score_gpt":0.2346143587088813,"score_spread":0.2187628944936384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}