{"id":"W4415831778","doi":"10.17615/yvmq-kt94","title":"Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas","year":2025,"lang":"","type":"article","venue":"UNC Libraries","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institute on Minority Health and Health Disparities; National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; Kaiser Foundation Research Institute; Ministério da Saúde; Manchester Biomedical Research Centre; Fundação de Amparo à Pesquisa do Estado de Minas Gerais; NHLBI Division of Intramural Research; Financiadora de Estudos e Projetos; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Hankuk University of Foreign Studies; Canadian Institutes of Health Research; National Institute of Dental and Craniofacial Research; Andrea and Charles Bronfman Philanthropies; University of Washington; University of Minnesota; National Center on Minority Health and Health Disparities; National Institute for Health and Care Research; National Institutes of Health; San Diego State University; National Heart, Lung, and Blood Institute; University of Miami; Northwestern University; Jackson State University; British Heart Foundation; Mississippi State Department of Health; Kidney Research UK; National Cancer Institute; Office of Dietary Supplements; U.S. Department of Health and Human Services","keywords":"Effector; Genome-wide association study; Genetic association; Population; Gene; Kidney disease; Function (biology); Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004217516,0.0002687865,0.0004168946,0.00007772716,0.0004366265,0.0001363345,0.0001223351,0.0002207943,0.000005206156],"category_scores_gemma":[0.0008601371,0.000195371,0.00005782407,0.0002463993,0.0007287509,0.00002322918,0.0001791702,0.0001649908,3.410027e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002041591,"about_ca_system_score_gemma":0.0003435456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002199115,"about_ca_topic_score_gemma":0.0001213182,"domain_scores_codex":[0.9981363,0.0004670924,0.0003889759,0.0006089524,0.00007882005,0.0003199009],"domain_scores_gemma":[0.9987109,0.0006405257,0.0002190021,0.0002761984,0.00004726535,0.0001060601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007088545,0.00007997907,0.9905015,0.00006099254,0.0005469323,4.64098e-7,0.002030101,0.00009299102,0.003232562,0.0003367506,0.0007419229,0.001666931],"study_design_scores_gemma":[0.005143059,0.001317384,0.9677646,0.00007041547,0.0005569998,0.000001458121,0.009066321,0.001796295,0.0004327875,0.006282517,0.007302887,0.0002652846],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683428,0.02110765,0.005942694,0.002740539,0.0002234814,0.001231121,0.0001965537,0.00001387718,0.0002013105],"genre_scores_gemma":[0.994068,0.000360964,0.003545376,0.0008994023,0.0002005122,0.0003293415,0.0002073664,0.00002009728,0.0003689845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02572518,"threshold_uncertainty_score":0.7967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585146421524289,"score_gpt":0.2346143587088813,"score_spread":0.2187628944936384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}