{"id":"W4415849430","doi":"10.1038/s43587-025-00986-z","title":"Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression","year":2025,"lang":"en","type":"article","venue":"Nature Aging","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; U.S. Department of Health and Human Services; Government of Canada; Tobacco-Related Disease Research Program; National Institute on Aging; National Institute of Environmental Health Sciences; American Cancer Society","keywords":"Carcinogenesis; PTEN; Transcriptome; Suppressor; Senescence; Lung cancer; Cancer; Regulator","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001779068,0.0002102181,0.0001914602,0.0001004135,0.0001721385,0.00006006319,0.0002642593,0.0002090594,0.0000173199],"category_scores_gemma":[0.0001714744,0.0002023102,0.0000862986,0.0001710059,0.00006479202,0.000009849226,0.0002657123,0.000349061,0.000001336744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004867985,"about_ca_system_score_gemma":0.0001137576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000021788,"about_ca_topic_score_gemma":0.00001098356,"domain_scores_codex":[0.9986452,0.00006779932,0.0002007504,0.000612761,0.0001593971,0.0003140787],"domain_scores_gemma":[0.999249,0.00005789342,0.00009281329,0.0004428379,0.00008511836,0.00007235545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004156886,0.00001594427,0.02658092,0.0001184423,0.000104807,0.00002443206,0.00005839125,0.0002748623,0.9609237,0.00004704055,0.009217298,0.00259264],"study_design_scores_gemma":[0.0004915456,0.00002993816,0.004398477,0.0003238429,0.00008261664,0.00002527049,0.00005463378,0.0005070222,0.9477339,0.00007400804,0.04600094,0.0002778069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9643614,0.03171507,0.001086958,0.0005657154,0.000996184,0.0001908658,0.00001647317,0.00005473027,0.00101258],"genre_scores_gemma":[0.9960395,0.0004039905,0.001075929,0.001432523,0.0003894469,0.00002384207,0.000045317,0.00002974644,0.0005597408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03678364,"threshold_uncertainty_score":0.8249972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003673206289110718,"score_gpt":0.2836346239369969,"score_spread":0.2799614176478862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}