{"id":"W4415871394","doi":"10.1136/jitc-2025-sitc2025.1316","title":"1316 Initial monotherapy clinical activity of invikafusp alfa, a first-in-class TCR β-chain-targeted bifunctional antibody, in tissue-agnostic, TMB-H patients from STARt-001, a phase 1/2 trial","year":2025,"lang":"","type":"article","venue":"","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Bifunctional; Clinical trial; T-cell receptor; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004396708,0.000623072,0.000984725,0.0002051455,0.0002556023,0.0007130608,0.0003450791,0.0005336967,0.004728313],"category_scores_gemma":[0.0003755947,0.0002241486,0.0006595669,0.0001827278,0.0003231609,0.000393824,0.0001534902,0.001899166,0.001220143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007387404,"about_ca_system_score_gemma":0.0006694634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008478186,"about_ca_topic_score_gemma":0.003603476,"domain_scores_codex":[0.9998527,0.00003846483,0.000006050925,0.00002263371,0.00002077354,0.00005937504],"domain_scores_gemma":[0.9998319,0.00003478788,0.0000174308,0.00001428825,0.00001486076,0.00008673502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2750634,0.00930175,0.006798916,0.00171138,0.001848255,0.0007607525,0.0003450862,0.005748941,0.1776768,0.001883967,0.04322524,0.4756355],"study_design_scores_gemma":[0.3624557,0.4514181,0.04945771,0.0004307138,0.002449515,0.002551366,0.0002268183,0.006161409,0.05296297,0.001762096,0.06998187,0.000141765],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9700495,0.008735633,0.0008875661,0.001142911,0.0003256432,0.0004815286,0.002781423,0.0004761606,0.01511956],"genre_scores_gemma":[0.9814761,0.003094823,0.0009088155,0.001123148,0.0001490209,0.0002744774,0.004586096,0.00005796178,0.008329581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004728313,"threshold_uncertainty_score":0.01581782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05299468534519122,"score_gpt":0.4237106002004399,"score_spread":0.3707159148552487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}