{"id":"W4415871413","doi":"10.1136/jitc-2025-sitc2025.1303","title":"1303 Phase I/Ib study of next generation JAK-STAT CAR-T therapy for patients with relapsed or refractory CD19 <sup>+</sup> B-cell lymphoma, chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL)","year":2025,"lang":"","type":"article","venue":"","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Chronic lymphocytic leukemia; Refractory (planetary science); Lymphoma; CD20; Phases of clinical research; CD19; Ibrutinib; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008098806,0.0009155497,0.00127863,0.0003798009,0.000440231,0.001074742,0.0006179832,0.0009124958,0.005927025],"category_scores_gemma":[0.0003066521,0.0003646857,0.001109364,0.0003491825,0.0007076579,0.0005349427,0.0002685904,0.00228654,0.001492117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009746355,"about_ca_system_score_gemma":0.00189738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002375562,"about_ca_topic_score_gemma":0.006312315,"domain_scores_codex":[0.9998094,0.00005573646,0.000008302376,0.00002794764,0.0000176594,0.00008086701],"domain_scores_gemma":[0.9997806,0.00002952556,0.00001921338,0.00001779637,0.00001428801,0.0001386284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5286797,0.08402587,0.01172394,0.001128812,0.001917448,0.000519453,0.0005721645,0.01014351,0.1271477,0.001892069,0.0191618,0.2130875],"study_design_scores_gemma":[0.44301,0.5108464,0.01465929,0.0000615985,0.0008442042,0.0005665655,0.0001372787,0.004495133,0.01248141,0.0007125117,0.0121383,0.00004732457],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986587,0.002170661,0.0007560334,0.000669637,0.0001726002,0.002170786,0.002623641,0.0001733197,0.004676298],"genre_scores_gemma":[0.9810392,0.001761122,0.002282951,0.001234565,0.00008913893,0.002401488,0.005854957,0.0000570697,0.005279567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005927025,"threshold_uncertainty_score":0.0198279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04467810406372259,"score_gpt":0.3102254886192023,"score_spread":0.2655473845554798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}