{"id":"W4415873316","doi":"10.1128/jvi.01407-25","title":"ARGLU1 is a negative regulator of the adenoviral replicative cycle","year":2025,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Repressor; Psychological repression; Viral replication; Adenoviridae; Recombinant DNA; DNA; Polymerase; Promoter; DNA damage; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002090887,0.0005518987,0.0002988216,0.000314168,0.0002749308,0.0004452668,0.0002748139,0.0002644448,0.002377648],"category_scores_gemma":[0.0002142037,0.0001558347,0.0002607708,0.0001027006,0.0002152829,0.0002222853,0.0002807985,0.0005956565,0.001478234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005322851,"about_ca_system_score_gemma":0.0001437961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001587574,"about_ca_topic_score_gemma":0.00012837,"domain_scores_codex":[0.9998389,0.00003912103,0.00001527151,0.00004211918,0.00003744207,0.00002708723],"domain_scores_gemma":[0.9997864,0.00005761029,0.00005827776,0.00002752259,0.00001844441,0.00005173968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000757214,0.00001656849,0.0001333642,0.00002439681,0.000001512661,0.00004257165,0.000005745566,0.00005144463,0.9980711,0.0001628892,0.00005584816,0.001358785],"study_design_scores_gemma":[0.00001364327,0.0001361985,0.003880812,0.00001532428,0.000006120497,0.0003843017,0.00002289497,0.003005761,0.9861925,0.0001731462,0.006158041,0.00001115728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685527,0.007883075,0.01647545,0.0002475969,0.0001386951,0.00006602687,0.001149488,0.0008690038,0.004618007],"genre_scores_gemma":[0.9881297,0.0007083498,0.005071154,0.00005927621,0.00002495997,0.00004882051,0.001190514,0.00009549463,0.004671642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002377648,"threshold_uncertainty_score":0.007954061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00860122088283036,"score_gpt":0.3075085039200521,"score_spread":0.2989072830372217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}