{"id":"W4415880585","doi":"10.1038/s44321-025-00330-3","title":"Benchmarking porcine pancreatic ductal organoids for drug screening applications","year":2025,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; Alberta Hospital Edmonton","funders":"Deutsche Forschungsgemeinschaft; Deutsches Zentrum für Diabetesforschung; Alexander von Humboldt-Stiftung","keywords":"Pancreas; Organoid; Proteomics; Endocrine system; Population; Pancreatitis; Phenotype; Drug development; Drug discovery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000832146,0.0004184656,0.0004829673,0.0005253344,0.0003134786,0.0008834485,0.0003320818,0.0006174899,0.001921639],"category_scores_gemma":[0.0006776449,0.0001941996,0.0005663491,0.0004143718,0.0003266605,0.0003368067,0.0006555748,0.0009499689,0.001266018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003706469,"about_ca_system_score_gemma":0.0004007687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008532298,"about_ca_topic_score_gemma":0.00154913,"domain_scores_codex":[0.9993875,0.00009106209,0.00007230378,0.0001625405,0.0002259731,0.00006057476],"domain_scores_gemma":[0.9994581,0.0001741382,0.00006804086,0.0001045598,0.0001198718,0.00007525477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000776359,0.00002926495,0.0005405676,0.0001322219,0.00001329413,0.0001146304,0.00003829901,0.0008425288,0.9943203,0.0002259225,0.0002239959,0.003441368],"study_design_scores_gemma":[0.000008745897,0.0003395027,0.002411168,0.00002696062,0.00004323907,0.0003446151,0.00009637489,0.002347527,0.9819386,0.0002194155,0.01220007,0.00002381956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7584129,0.006443653,0.1893622,0.0007745823,0.0004036464,0.001198258,0.02105246,0.001912259,0.02044002],"genre_scores_gemma":[0.8399355,0.005354026,0.1182546,0.0007052687,0.00003295247,0.001174351,0.02399049,0.0004581094,0.01009475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001921639,"threshold_uncertainty_score":0.006428599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007668431280548635,"score_gpt":0.2579112588411712,"score_spread":0.2502428275606226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}