{"id":"W4415884720","doi":"10.1016/j.immuni.2025.10.006","title":"Long-lived IgE plasma cells persist in secondary lymphoid tissues using a navitoclax-sensitive survival program","year":2025,"lang":"en","type":"article","venue":"Immunity","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Medical Research Council; Sandler Foundation; Canadian Institutes of Health Research; Foundation for the National Institutes of Health; Monash University; National Institutes of Health","keywords":"Immunoglobulin E; Homing (biology); Bone marrow; Allergy; CD23; CXCR4; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004541708,0.0004014611,0.0006784206,0.0003407739,0.0005185018,0.00004681543,0.0004973739,0.00063765,0.000454882],"category_scores_gemma":[0.00006966329,0.0004060956,0.0001941831,0.0004796192,0.0008120026,0.000146737,0.0004353147,0.001164354,0.0004375485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002825399,"about_ca_system_score_gemma":0.000393639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006073619,"about_ca_topic_score_gemma":0.001188226,"domain_scores_codex":[0.9970579,0.001093609,0.0005272874,0.00048822,0.00004741292,0.000785586],"domain_scores_gemma":[0.9986629,0.000382188,0.0001630586,0.0006188226,0.0001440375,0.00002894092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000548975,0.0008796167,0.004130328,0.00005863771,0.0003726849,0.00007909103,0.001517073,0.00001021399,0.9725908,0.00009147571,0.0002649923,0.01945609],"study_design_scores_gemma":[0.004637131,0.0003734281,0.01244295,0.0002013968,0.000117428,0.0001506501,0.005246934,0.00005585223,0.9596179,0.00008726601,0.01651588,0.0005531905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843202,0.003008346,0.00003492756,0.00009789163,0.002318927,0.0006804497,0.00004835782,0.0002037826,0.009287163],"genre_scores_gemma":[0.9928619,0.0001281319,0.0002054458,0.0001056914,0.00002724098,0.00003787581,0.0002299465,0.00002793812,0.006375831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0189029,"threshold_uncertainty_score":0.9998391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01943350393826992,"score_gpt":0.2736620837884623,"score_spread":0.2542285798501924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}