{"id":"W4415897532","doi":"10.1016/j.jbior.2025.101128","title":"Activity and dynamics of p110α are not differentially modulated by regulatory subunit isoforms","year":2025,"lang":"en","type":"article","venue":"Advances in Biological Regulation","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Cancer Research Society","keywords":"Protein subunit; Gene isoform; Phosphopeptide; Kinase; P110α; HEK 293 cells; Phosphorylation; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473937,0.0001447544,0.0002103506,0.00005313702,0.00004322147,0.000007844216,0.0001283335,0.0002768995,0.00001056192],"category_scores_gemma":[0.0001328728,0.0001175455,0.00004485407,0.0001462091,0.0002230529,0.00001442423,0.00009855709,0.00009082738,2.634872e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005281774,"about_ca_system_score_gemma":0.00002136299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001215474,"about_ca_topic_score_gemma":0.0001029861,"domain_scores_codex":[0.999075,0.00007281727,0.0002367829,0.0003536446,0.00009293676,0.0001688495],"domain_scores_gemma":[0.9994609,0.00004398563,0.0001710243,0.0002268406,0.00006706259,0.00003015439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004895562,0.00007849048,0.1045701,0.00003749417,0.00002123369,2.555573e-7,0.000005021481,0.0009571572,0.8624858,0.0006931348,0.00002998855,0.03063181],"study_design_scores_gemma":[0.0005799699,0.000263512,0.670513,0.0000676964,0.000009154145,9.159594e-7,0.00001466754,0.004865323,0.3185265,0.003921271,0.001054635,0.0001833759],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884197,0.001735751,0.009196965,0.000106601,0.0001246455,0.0001609984,0.00004202419,0.00001456905,0.0001987676],"genre_scores_gemma":[0.998367,0.0008883483,0.0002556056,0.00005224478,0.00002531171,0.00001500946,0.0001850404,0.00000714283,0.0002043365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5659429,"threshold_uncertainty_score":0.4793366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007432480118094409,"score_gpt":0.2658778955097623,"score_spread":0.2584454153916679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}