{"id":"W4415898666","doi":"10.1136/jitc-2025-sitc2025.1196","title":"1196 TriTCE Co-stim: a differentiated T cell engager platform with conditional <i>cis</i> CD28 co-stimulation is transferable to diverse targeting strategies","year":2025,"lang":"","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"T cell; CD28; Cell; T-cell receptor; Ubiquitin-Protein Ligases","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002057787,0.000404763,0.0002940796,0.0002705006,0.0002640973,0.0006280123,0.0003338334,0.0005334614,0.006951764],"category_scores_gemma":[0.000130216,0.0002436894,0.0002676897,0.000215524,0.0002411332,0.0002867163,0.0004148273,0.001456428,0.003481753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003667899,"about_ca_system_score_gemma":0.000363284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004685927,"about_ca_topic_score_gemma":0.001236599,"domain_scores_codex":[0.999521,0.00004521903,0.00003029427,0.0001193486,0.0001451537,0.0001390095],"domain_scores_gemma":[0.9999043,0.00001404038,0.00001701072,0.00001563786,0.00001310029,0.00003583614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009475535,0.00003333504,0.00008658053,0.00002390197,0.000006687398,0.00002981075,0.0000114232,0.00009049202,0.9971008,0.000263854,0.0004483075,0.001810168],"study_design_scores_gemma":[0.00001792603,0.0001200757,0.0006567537,0.000003511328,0.00001224358,0.0001312105,0.00001558684,0.0008879261,0.9920229,0.00004657052,0.006080032,0.000005240188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9493613,0.001603209,0.02362881,0.0005367188,0.0003004696,0.0002022104,0.003023749,0.001014464,0.02032911],"genre_scores_gemma":[0.9647663,0.0006190774,0.009608202,0.0002516353,0.00003053797,0.0001560485,0.003141258,0.0001914201,0.02123555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006951764,"threshold_uncertainty_score":0.02325594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02448960916072105,"score_gpt":0.2953962097737661,"score_spread":0.2709066006130451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}