{"id":"W4415898865","doi":"10.1136/jitc-2025-sitc2025.0320","title":"320 Integrated efficacy and safety analysis of letetresgene autoleucel, a T-cell receptor T-cell therapy, across clinical trials of patients with synovial sarcoma and myxoid/round cell liposarcoma","year":2025,"lang":"","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Princess Margaret Cancer Centre","funders":"","keywords":"Clinical trial; Soft tissue sarcoma; Synovial sarcoma; Liposarcoma; Sarcoma; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004228472,0.0006203348,0.001795444,0.0006475158,0.0002613091,0.001203674,0.0004594382,0.0007483552,0.002080157],"category_scores_gemma":[0.002361534,0.0003808304,0.001570658,0.0005486094,0.0007819411,0.001059319,0.0003615954,0.001530707,0.0005006729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001097912,"about_ca_system_score_gemma":0.0009159388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005116737,"about_ca_topic_score_gemma":0.0008708477,"domain_scores_codex":[0.9977813,0.001234627,0.000174121,0.0002719316,0.0002868398,0.0002510588],"domain_scores_gemma":[0.9987549,0.0003501496,0.0003354238,0.0001688817,0.0001469123,0.0002438278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.7737965,0.01602318,0.01284671,0.0005307731,0.003875699,0.0001080631,0.0002241859,0.004146899,0.0607879,0.0004077172,0.001364064,0.1258883],"study_design_scores_gemma":[0.159694,0.7545114,0.05866751,0.00005425447,0.003763966,0.0002822471,0.0001408298,0.003183734,0.01402726,0.0003986788,0.005205862,0.00007030847],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959697,0.001422289,0.0004790251,0.0001109337,0.00004768516,0.0003915704,0.0006334315,0.00004317834,0.0009022396],"genre_scores_gemma":[0.9964421,0.0005308878,0.0005488936,0.0001507448,0.0000546002,0.0003184773,0.001145701,0.00002181902,0.0007866992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004228472,"threshold_uncertainty_score":0.02236259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04326194252474586,"score_gpt":0.3526277013207987,"score_spread":0.3093657587960528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}