{"id":"W4415899076","doi":"10.1136/jitc-2025-sitc2025.0854","title":"854 Amplification & redirection of endogenous IL-15 activity with a bispecific antibody","year":2025,"lang":"","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada; Acuitas Therapeutics (Canada)","funders":"","keywords":"Bispecific antibody; Endogeny; Antibody; Antibody response; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007853733,0.0009571307,0.0004708047,0.0007914776,0.0004233743,0.0007115809,0.0006644597,0.000679283,0.006807615],"category_scores_gemma":[0.0004021327,0.0004609577,0.0006466139,0.0005479209,0.0005148901,0.0003439185,0.0008242257,0.001878122,0.002786129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008772501,"about_ca_system_score_gemma":0.0008849626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001365005,"about_ca_topic_score_gemma":0.002089567,"domain_scores_codex":[0.9989078,0.000163622,0.000131028,0.0002131769,0.0001915112,0.0003929061],"domain_scores_gemma":[0.9996446,0.0001184825,0.00003752834,0.00006117969,0.00005706774,0.00008112749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002815233,0.0000920274,0.0001249244,0.00005862295,0.00001253654,0.00004272543,0.00002127423,0.0001299833,0.9956631,0.00059985,0.0002568771,0.002716453],"study_design_scores_gemma":[0.00004257906,0.0001182542,0.0005279522,0.000004939548,0.00001183357,0.00006480704,0.000007541254,0.000813768,0.9949546,0.00005140534,0.003398113,0.00000409996],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.8884668,0.001925806,0.0787404,0.0007905752,0.0005501246,0.001164983,0.002592336,0.001156296,0.02461264],"genre_scores_gemma":[0.8901268,0.001577315,0.0713537,0.0006556147,0.0001254076,0.001050094,0.005244755,0.000375983,0.02949033],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.006807615,"threshold_uncertainty_score":0.0227738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02288873498355517,"score_gpt":0.2513961319891393,"score_spread":0.2285073970055842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}