{"id":"W4415899279","doi":"10.1136/jitc-2025-sitc2025.1036","title":"1036 KAN-004, a metabolically complete live biotherapeutic product for the treatment of immune-related colitis","year":2025,"lang":"","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Product (mathematics); Colitis; Ulcerative colitis; Inflammatory bowel disease; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001331078,0.0003252981,0.0002589448,0.0002584668,0.0001526045,0.0002656474,0.0003807099,0.0005212792,0.010117],"category_scores_gemma":[0.0001030631,0.0001349275,0.0002802869,0.0001856984,0.0001950936,0.0001946744,0.0002205403,0.0009484523,0.002030932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002261571,"about_ca_system_score_gemma":0.0004455803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006040582,"about_ca_topic_score_gemma":0.0008023691,"domain_scores_codex":[0.9999214,0.00001525546,0.000003716543,0.00001187179,0.00002458732,0.00002311634],"domain_scores_gemma":[0.9999536,0.000007022395,0.000007791371,0.000005100927,0.000005595379,0.0000208801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003819811,0.0006514824,0.0003503531,0.0002955824,0.0000394667,0.0003767414,0.00003592943,0.000551715,0.8771853,0.001244481,0.00362929,0.11182],"study_design_scores_gemma":[0.003916232,0.02364633,0.009402603,0.00008283947,0.0001626041,0.004229213,0.00007815829,0.002293057,0.8300635,0.0005279191,0.1255413,0.00005639988],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.8958486,0.02283301,0.01482736,0.001786564,0.0009241283,0.0005877182,0.004033048,0.001626665,0.05753299],"genre_scores_gemma":[0.9366775,0.007800138,0.007809013,0.0004873828,0.00006028117,0.0001711202,0.003693346,0.00008889535,0.04321237],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.010117,"threshold_uncertainty_score":0.03384471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124908853177363,"score_gpt":0.2491996479293751,"score_spread":0.2367087626116388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}