{"id":"W4415899361","doi":"10.1016/j.euo.2025.10.010","title":"Prostate-specific Antigen and Objective Response Analyses in PROpel: Olaparib Plus Abiraterone Versus Placebo Plus Abiraterone as First-line Therapy for Metastatic Castration-resistant Prostate Cancer","year":2025,"lang":"en","type":"article","venue":"European Urology Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"AstraZeneca","keywords":"Abiraterone; Prostate cancer; Placebo; Olaparib; Prostate-specific antigen; Biomarker; Population","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001415089,0.0004724785,0.00100991,0.0006478121,0.0003163723,0.00006330387,0.000205647,0.0001557579,0.00009602248],"category_scores_gemma":[0.0002802233,0.0003636082,0.0001034689,0.0006138616,0.0007408286,0.0001456727,0.0001367269,0.0005217398,0.00004070887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001024906,"about_ca_system_score_gemma":0.0020232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003392497,"about_ca_topic_score_gemma":0.001221555,"domain_scores_codex":[0.9955366,0.001574643,0.0007724518,0.001017654,0.0002253797,0.0008733179],"domain_scores_gemma":[0.9977816,0.0009840033,0.000253361,0.0004250004,0.0003545229,0.0002015525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8570793,0.0009759513,0.003096657,0.0002539322,0.001537118,0.002909094,0.008130124,0.001258087,0.1066302,0.000138153,0.00177324,0.01621817],"study_design_scores_gemma":[0.3352894,0.08859944,0.3416659,0.0003895684,0.001089869,0.000212339,0.004048052,0.002708804,0.02699947,0.0005632117,0.1970042,0.001429691],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699649,0.01307438,0.00007862672,0.009167605,0.0004770922,0.005368272,0.000141468,0.00009557176,0.001632074],"genre_scores_gemma":[0.9858969,0.006759535,0.0004632761,0.000787962,0.0001101557,0.001115884,0.0001812953,0.00008966176,0.004595289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5217898,"threshold_uncertainty_score":0.9998816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09922039059211404,"score_gpt":0.4154966879285947,"score_spread":0.3162762973364807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}