{"id":"W4415900237","doi":"10.1136/jitc-2025-sitc2025.0614","title":"614 Treatment with diacylglycerol kinase (DGK) alpha specific inhibitor BAY2862789 exhibits combination potential with DGK zeta inhibition in biomarker assays during FIH monotherapy trial","year":2025,"lang":"","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Diacylglycerol kinase; Biomarker; Alpha (finance); Kinase; In vivo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002513538,0.000436676,0.001000993,0.0002202358,0.0001986363,0.0004370737,0.000267096,0.0004794851,0.003929925],"category_scores_gemma":[0.0001977323,0.0001249852,0.0004481812,0.0002071917,0.000203908,0.0002538094,0.0001673426,0.001147585,0.0009660306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002897009,"about_ca_system_score_gemma":0.0004438948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003092551,"about_ca_topic_score_gemma":0.001183107,"domain_scores_codex":[0.9999008,0.00001857383,0.000008778294,0.00001765222,0.00001546907,0.0000386748],"domain_scores_gemma":[0.9999219,0.00001075621,0.00001280962,0.000008006964,0.000006683934,0.00003990084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2711541,0.01196265,0.007859455,0.0009903802,0.000825006,0.0007658578,0.0001477841,0.001750516,0.3771054,0.0005902594,0.01039293,0.3164557],"study_design_scores_gemma":[0.1173554,0.4130753,0.1041521,0.0001992058,0.001992608,0.002410614,0.0002439955,0.006337781,0.3089914,0.001000193,0.04405205,0.0001893741],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891813,0.00416469,0.0004873742,0.0005516988,0.0002519837,0.0002720032,0.0007351482,0.0001820467,0.004173778],"genre_scores_gemma":[0.9914865,0.001989326,0.0007799965,0.0003014196,0.0001015279,0.00021946,0.001098263,0.00001622219,0.004007263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003929925,"threshold_uncertainty_score":0.01314688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008923470580566912,"score_gpt":0.2272747459823055,"score_spread":0.2183512754017385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}