{"id":"W4415900261","doi":"10.1136/jitc-2025-sitc2025.0658","title":"658 KAN-001, a defined live biotherapeutic product (LBP) for NSCLC, enhances ICI response in preclinical models and demonstrates manufacturing consistency and strain-resolved viability","year":2025,"lang":"","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"University of Texas MD Anderson Cancer Center","keywords":"Consistency (knowledge bases); Product (mathematics); New product development; Selection (genetic algorithm); Manufacturing process","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001327206,0.0006674197,0.0007583295,0.0001747861,0.0004664433,0.0002965988,0.0001976193,0.0006276556,0.000007175938],"category_scores_gemma":[0.001329352,0.0006427793,0.0001959994,0.0001308936,0.001632894,0.00006309112,0.0002179772,0.0003681394,8.407951e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005083644,"about_ca_system_score_gemma":0.0009553191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002094727,"about_ca_topic_score_gemma":0.0002638666,"domain_scores_codex":[0.9958309,0.0005008694,0.001110237,0.001635078,0.0002037033,0.0007192474],"domain_scores_gemma":[0.9978106,0.0004306693,0.0003388891,0.0006184876,0.0001650111,0.0006363164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008576329,0.001065447,0.01873786,0.00302618,0.0008655068,0.0000395383,0.0007980356,0.0006567592,0.9503831,0.0006018454,0.000584516,0.01466487],"study_design_scores_gemma":[0.008490039,0.002886014,0.1644265,0.002156241,0.0008027686,0.0001564665,0.0009347622,0.003816256,0.7773416,0.03263336,0.004283357,0.002072653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9676911,0.02810802,0.0001936862,0.001476956,0.0004136793,0.001663115,0.0002689966,0.00003213955,0.0001523401],"genre_scores_gemma":[0.9947295,0.003044417,0.0009493049,0.0005809682,0.0001436981,0.0001714398,0.00006996662,0.000044987,0.0002657417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1730415,"threshold_uncertainty_score":0.9996024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02538065797244054,"score_gpt":0.2998519849065107,"score_spread":0.2744713269340702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}