{"id":"W4415901190","doi":"10.1016/j.jhepr.2025.101635","title":"Clinical practice and implications of biomarker testing in biliary tract cancer: An observational study","year":2025,"lang":"en","type":"article","venue":"JHEP Reports","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Toronto General Hospital","funders":"Cilag; Horizon 2020 Framework Programme; Ipsen; Servier; Deutsche Krebshilfe; Eisai; LEO Pharma; European Cooperation in Science and Technology; Incyte; Deutsche Bahn; Les Laboratories Pierre Fabre; Eli Lilly and Company; AstraZeneca; Celgene; Daiichi Sankyo Europe; Sanofi; Deutsche Forschungsgemeinschaft; Wilhelm Sander-Stiftung; Amgen","keywords":"Observational study; Clinical Practice; Clinical trial; Profiling (computer programming); Biliary tract; Precision medicine; Randomized controlled trial; Biomarker","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00542479,0.0002536439,0.0005832454,0.001248962,0.0005698351,0.001218831,0.0005094182,0.0005307695,0.001219695],"category_scores_gemma":[0.01669926,0.000306347,0.0005165312,0.003023467,0.0007162498,0.0008593402,0.00107604,0.0005287132,0.0002379781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008264258,"about_ca_system_score_gemma":0.001071038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002571502,"about_ca_topic_score_gemma":0.002362656,"domain_scores_codex":[0.9927451,0.003336626,0.001299802,0.001389802,0.0007465182,0.0004821675],"domain_scores_gemma":[0.9764855,0.007350572,0.01178565,0.001685762,0.00145977,0.001232772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009169918,0.00001786693,0.9984992,0.00001762899,0.00003398926,0.00005629314,0.000081625,0.00003353863,0.00004486103,0.00002920547,0.00009228205,0.0010019],"study_design_scores_gemma":[0.00002414178,0.0001946747,0.9967557,0.0000406881,0.00009681896,0.0008841112,0.0006725431,0.0004047951,0.00008503273,0.0001144723,0.0007132531,0.00001369646],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975611,0.001101726,0.0003091492,0.0001442011,0.000009969602,0.00002386637,0.0004860618,0.000003506756,0.0003603892],"genre_scores_gemma":[0.9992958,0.0001569545,0.0001268455,0.00005385518,0.00001083279,0.00001726186,0.0003149407,0.000002496825,0.00002079689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00542479,"threshold_uncertainty_score":0.02868932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2481510801004267,"score_gpt":0.4805192816871646,"score_spread":0.232368201586738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}