{"id":"W4415901316","doi":"10.1016/j.euo.2025.09.018","title":"Genomic and Epigenomic Signatures Can Distinguish Aggressive Chromophobe Renal Cell Carcinoma from Indolent Renal Oncocytic Tumors in Clinical-grade Samples","year":2025,"lang":"en","type":"article","venue":"European Urology Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"University of Texas MD Anderson Cancer Center; National Institutes of Health","keywords":"Epigenomics; Renal cell carcinoma; Chromophobe cell; Renal oncocytoma; Clear cell; Oncocytoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004427282,0.0002072407,0.0002710308,0.001074388,0.0002782434,0.0008913738,0.0002109973,0.0003802431,0.002093428],"category_scores_gemma":[0.001264791,0.0001061794,0.0001860957,0.0006853049,0.0002942056,0.0003557086,0.0004846894,0.0003100445,0.0003443992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001916265,"about_ca_system_score_gemma":0.0002658179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143389,"about_ca_topic_score_gemma":0.003231246,"domain_scores_codex":[0.9996257,0.00005447229,0.00003641728,0.000101201,0.0000895469,0.00009271362],"domain_scores_gemma":[0.9995932,0.0001254042,0.00009631088,0.00004622898,0.00008379628,0.00005518929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000638327,0.00005988866,0.8799465,0.0001040553,0.0002011248,0.0003654631,0.0002398729,0.0003823297,0.08348577,0.0004681915,0.0007922912,0.03331614],"study_design_scores_gemma":[0.00001306772,0.0001190619,0.9801512,0.00001937883,0.0001427752,0.001221309,0.0004094059,0.001260335,0.01142953,0.000621082,0.004604565,0.000008371416],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909533,0.001370462,0.002172319,0.000291724,0.0000296343,0.00003552639,0.001663674,0.00005881974,0.003424623],"genre_scores_gemma":[0.9969534,0.0002351008,0.0007136787,0.0001229144,0.00001717092,0.0000176624,0.001205173,0.00001333882,0.0007216383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002093428,"threshold_uncertainty_score":0.007003248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02836266111692293,"score_gpt":0.2982851752699084,"score_spread":0.2699225141529855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}