{"id":"W4415901316","doi":"10.1016/j.euo.2025.09.018","title":"Genomic and Epigenomic Signatures Can Distinguish Aggressive Chromophobe Renal Cell Carcinoma from Indolent Renal Oncocytic Tumors in Clinical-grade Samples","year":2025,"lang":"en","type":"article","venue":"European Urology Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"University of Texas MD Anderson Cancer Center; National Institutes of Health","keywords":"Epigenomics; Renal cell carcinoma; Chromophobe cell; Renal oncocytoma; Clear cell; Oncocytoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008224671,0.0005288745,0.001342303,0.0004739504,0.0001535384,0.00002311117,0.0003857327,0.0003710196,0.0001200656],"category_scores_gemma":[0.0005347848,0.0004801084,0.0002344451,0.0002448423,0.0008365299,0.00002884675,0.0005024468,0.001391711,0.0000861157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008339029,"about_ca_system_score_gemma":0.0006816248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008634159,"about_ca_topic_score_gemma":0.0008204546,"domain_scores_codex":[0.9940647,0.002329603,0.001350091,0.001294126,0.0001710671,0.0007904411],"domain_scores_gemma":[0.9966984,0.001437508,0.0007092496,0.0007132547,0.00007096324,0.0003705628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003106442,0.001872988,0.8617812,0.0001555849,0.0004832855,0.04655325,0.002817155,0.0002009184,0.06125439,0.000191596,0.003309197,0.01827393],"study_design_scores_gemma":[0.008876971,0.003574766,0.974434,0.00009669852,0.0005012148,0.000290895,0.0001115016,0.0001453644,0.002047997,0.0002344559,0.009359008,0.0003270926],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702351,0.01232548,0.00001880753,0.001924334,0.0005874751,0.0007967483,0.00006426547,0.00007311423,0.01397469],"genre_scores_gemma":[0.9944144,0.0005254484,0.000750249,0.002915477,0.0006055209,0.00003564941,0.0001686798,0.00008099059,0.0005036223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1126528,"threshold_uncertainty_score":0.999765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02836266111692293,"score_gpt":0.2982851752699084,"score_spread":0.2699225141529855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}