{"id":"W4415916118","doi":"10.1016/j.kint.2025.09.027","title":"Mouse Alport podocytes are susceptible to AAV9 transduction in vivo","year":2025,"lang":"en","type":"article","venue":"Kidney International","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Chinook Therapeutics; St. Louis Children's Hospital; Children's Discovery Institute; Alport Syndrome Foundation; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Oregon Health and Science University; Japan Society for the Promotion of Science; Bayer","keywords":"Alport syndrome; Mesangial cell; Transduction (biophysics); In vivo; Podocyte; Genetic enhancement; Renal glomerulus; Glomerulonephritis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005853465,0.0005608607,0.0002451497,0.0005975065,0.0002101159,0.0006141666,0.0002893302,0.0009019983,0.002553745],"category_scores_gemma":[0.0002775058,0.0003041867,0.0003624005,0.0001676764,0.0002979576,0.0003773229,0.000279092,0.001051755,0.00125884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002776879,"about_ca_system_score_gemma":0.0001845963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005020308,"about_ca_topic_score_gemma":0.0005882123,"domain_scores_codex":[0.9993833,0.00007466911,0.00007652093,0.0001597305,0.0002220148,0.00008363755],"domain_scores_gemma":[0.9994517,0.00007829829,0.0002030872,0.00008384036,0.0000693238,0.0001137339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004928032,0.00002750331,0.0001598234,0.00002394628,0.00000625964,0.00005728597,0.00002614489,0.00003504824,0.998828,0.0001362259,0.00003837677,0.0006120876],"study_design_scores_gemma":[0.00002156553,0.0002963117,0.003727514,0.0000160793,0.00002038099,0.0008323033,0.00003104374,0.0009444966,0.991035,0.00008481598,0.002984234,0.000006131686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714977,0.001144645,0.02111103,0.000158774,0.00008455655,0.0001629844,0.00140291,0.0005942942,0.003842974],"genre_scores_gemma":[0.9710119,0.0008482276,0.01044857,0.0001230265,0.00002348486,0.0001948153,0.002707427,0.0002020466,0.01444055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002553745,"threshold_uncertainty_score":0.008543074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009598675458208231,"score_gpt":0.2881707565551896,"score_spread":0.2785720810969813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}