{"id":"W4415922466","doi":"10.1016/j.anai.2025.10.021","title":"REZPEGALDESLEUKIN, NOVEL TREG-INDUCING THERAPY, DEMONSTRATES EFFICACY IN ATOPIC DERMATITIS AND ASTHMA IN PHASE 2B TRIAL","year":2025,"lang":"en","type":"article","venue":"Annals of Allergy Asthma & Immunology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kingston Health Sciences Centre","funders":"","keywords":"Asthma; Atopic dermatitis; Placebo; Minimal clinically important difference; Eczema Area and Severity Index; Randomized controlled trial; Adverse effect; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001610101,0.0008151244,0.001231196,0.000205662,0.0002847481,0.0008114973,0.0004708264,0.001069968,0.004151967],"category_scores_gemma":[0.000533959,0.0001800608,0.001208254,0.0001905109,0.0003780891,0.0006271749,0.0001890641,0.002781054,0.0007090502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004777031,"about_ca_system_score_gemma":0.0005186257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004227409,"about_ca_topic_score_gemma":0.001770718,"domain_scores_codex":[0.9996299,0.0001638896,0.00001771068,0.00004487604,0.00004445044,0.00009914664],"domain_scores_gemma":[0.9997003,0.00009542362,0.00004795067,0.00002538078,0.00002376576,0.0001073077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4631887,0.01836682,0.005261198,0.003287887,0.00299459,0.0005706439,0.0002764614,0.002120106,0.0629082,0.001921807,0.02062859,0.4184751],"study_design_scores_gemma":[0.732677,0.2162327,0.01682693,0.0003435905,0.001123731,0.0009094346,0.0001186913,0.00170244,0.008394845,0.0009075502,0.02070925,0.0000537986],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9542826,0.02818482,0.001300681,0.003121314,0.0007761662,0.00145114,0.001966084,0.0003827139,0.008534503],"genre_scores_gemma":[0.977357,0.008451335,0.001992909,0.00297002,0.0003914071,0.001254185,0.002054534,0.00004810523,0.005480583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004151967,"threshold_uncertainty_score":0.01388973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03372803280975173,"score_gpt":0.3369240059582815,"score_spread":0.3031959731485298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}