{"id":"W4415930041","doi":"10.1016/j.neuron.2025.10.007","title":"Glutamate promotes glioma growth via a non-excitable, receptor tyrosine kinase-mediated mechanism","year":2025,"lang":"en","type":"article","venue":"Neuron","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Glutamate receptor; Mechanism (biology); Metabotropic glutamate receptor 6; Glioma; Astrocytoma; Receptor; Metabotropic glutamate receptor; Receptor tyrosine kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001385625,0.000463922,0.0003111918,0.0002594742,0.0001868558,0.0004153053,0.0003530535,0.0003767361,0.001472269],"category_scores_gemma":[0.0001443563,0.000119514,0.0005722122,0.0002794285,0.0001754529,0.0003722659,0.0002979738,0.0005432801,0.0004497302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000592189,"about_ca_system_score_gemma":0.0005168733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004319033,"about_ca_topic_score_gemma":0.008130625,"domain_scores_codex":[0.9998232,0.00002604764,0.00001426563,0.00002311322,0.00004935733,0.00006401485],"domain_scores_gemma":[0.99993,0.00001143086,0.00001739546,0.00001113413,0.00001333667,0.00001668722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005104879,0.0001246916,0.0003644469,0.0001433699,0.00003602794,0.0001749297,0.0000307697,0.0001361471,0.9931939,0.0005900023,0.0002026179,0.004492705],"study_design_scores_gemma":[0.0001314056,0.001236942,0.01541533,0.00002231524,0.00007390881,0.00038157,0.0001168942,0.001278583,0.9777592,0.000252494,0.003316627,0.0000147743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839077,0.005317186,0.003480352,0.0003374756,0.00009077001,0.0000592531,0.0005211449,0.0001270061,0.006159065],"genre_scores_gemma":[0.9942914,0.001720448,0.0007582441,0.00006067712,0.000008871601,0.0000257165,0.0002246503,0.00001026418,0.002899702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004319033,"threshold_uncertainty_score":0.008587778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02155659133882646,"score_gpt":0.2986979929841077,"score_spread":0.2771414016452812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}