{"id":"W4415930753","doi":"10.1101/2025.11.03.686378","title":"Lymphatic constraint of germinal centers optimizes protective antibody responses","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"European Commission; Cancer Research Institute; European Federation of Pharmaceutical Industries and Associations; National Cancer Institute; National Institutes of Health; Volkswagen Foundation","keywords":"Germinal center; Lymphangiogenesis; Lymphatic system; Antigen; Antibody; Lymphatic vessel; Lymph; Lymphatic Endothelium; Follicle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005930968,0.0006209809,0.001324417,0.0005970324,0.0001014158,0.00007207967,0.0003626922,0.0004557047,0.00006968845],"category_scores_gemma":[0.001218358,0.0005867132,0.0004083008,0.0004496379,0.0004290928,0.0000851939,0.0003610555,0.000136687,0.00001780089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004631544,"about_ca_system_score_gemma":0.004421804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001124769,"about_ca_topic_score_gemma":3.931766e-7,"domain_scores_codex":[0.9966868,0.0003257828,0.0009522353,0.0009280199,0.0006019155,0.0005052559],"domain_scores_gemma":[0.9964205,0.0002983547,0.0006730615,0.001340803,0.0008847372,0.0003825564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002879705,0.001777305,0.08676039,0.01799323,0.002361608,0.0008729692,0.0000910829,0.00007310137,0.8855404,0.001134587,0.0005036652,0.00001198428],"study_design_scores_gemma":[0.007214731,0.0004977675,0.2971708,0.0201122,0.002584136,7.120626e-7,0.0001157724,0.0008787492,0.66969,0.000007148301,0.000330478,0.001397535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989438,0.002557683,0.002006252,0.0002426216,0.001033866,0.003181074,0.001047066,0.0003420453,0.0001514168],"genre_scores_gemma":[0.9944553,0.0001336444,0.004556763,0.0001940852,0.0002171201,0.0003451525,0.000001120991,0.00006321745,0.000033633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2158504,"threshold_uncertainty_score":0.9996584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01643796045276201,"score_gpt":0.2741063260011751,"score_spread":0.2576683655484131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}