{"id":"W4415930757","doi":"10.1101/gad.352953.125","title":"Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer","year":2025,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Cancer Institute; National Institutes of Health; V Foundation for Cancer Research; U.S. Department of Defense","keywords":"Transactivation; Fulvestrant; Mutant; Estrogen receptor; Ovarian cancer; Missense mutation; Gene silencing; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008339466,0.0001623457,0.000135587,0.0001458905,0.0001088704,0.0002218837,0.00012349,0.0001675845,0.001106278],"category_scores_gemma":[0.0001008375,0.00009957571,0.0001352142,0.000102135,0.0001865362,0.0001084353,0.0001436382,0.0003069039,0.000306715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002414475,"about_ca_system_score_gemma":0.0001287202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006234632,"about_ca_topic_score_gemma":0.0008037473,"domain_scores_codex":[0.9999378,0.000009910604,0.000005226328,0.00001056606,0.00001670498,0.00001985611],"domain_scores_gemma":[0.9999418,0.00001197177,0.00001666458,0.00001039378,0.000004202699,0.00001492741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006198254,0.00002292818,0.0003463778,0.00001288896,0.000002621315,0.00008969694,0.000008670983,0.0001048772,0.997924,0.000133173,0.00005584983,0.001236998],"study_design_scores_gemma":[0.00002398107,0.0002670282,0.006553535,0.000004866162,0.00000801815,0.0005801209,0.00003897858,0.001614107,0.9876524,0.00009401864,0.003159343,0.000003569472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966922,0.0007181042,0.001088155,0.0001106346,0.00001641325,0.00001100037,0.0001394689,0.00006499065,0.001159099],"genre_scores_gemma":[0.9983606,0.0002737889,0.0002601791,0.00002467908,0.000002005181,0.000005718846,0.0001052595,0.000008817353,0.0009588479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001106278,"threshold_uncertainty_score":0.003700912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009355003619116984,"score_gpt":0.2683824820941945,"score_spread":0.2590274784750775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}