{"id":"W4415930757","doi":"10.1101/gad.352953.125","title":"Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer","year":2025,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Cancer Institute; National Institutes of Health; V Foundation for Cancer Research; U.S. Department of Defense","keywords":"Transactivation; Fulvestrant; Mutant; Estrogen receptor; Ovarian cancer; Missense mutation; Gene silencing; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001705603,0.0002198986,0.0003960712,0.000249913,0.0000775556,0.0000200641,0.00009073912,0.00008408396,0.00007524033],"category_scores_gemma":[0.00006553283,0.0002161292,0.00003881449,0.0004944343,0.00003565416,0.00003457216,0.0001200435,0.0001766293,0.00001777172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007890962,"about_ca_system_score_gemma":0.001111859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002000004,"about_ca_topic_score_gemma":0.001871254,"domain_scores_codex":[0.9985037,0.0000431301,0.0003157436,0.0004931247,0.0002399171,0.0004043821],"domain_scores_gemma":[0.9993615,0.00003358611,0.00006337876,0.0002701826,0.00009697393,0.0001744128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001196948,0.0001232625,0.01460596,0.0001230435,0.0002990793,0.0001505991,0.001043559,0.00003323355,0.8566704,0.0004859924,0.0009955099,0.1242725],"study_design_scores_gemma":[0.003416313,0.00005460872,0.09934152,0.000569325,0.00005801679,0.000009453892,0.00006736819,0.00001410149,0.6357176,0.00004494088,0.2604505,0.000256196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851849,0.005201525,0.001458627,0.005296386,0.0003965494,0.001137681,0.00002451019,0.00004825574,0.001251555],"genre_scores_gemma":[0.9815397,0.0008801501,0.01377496,0.001111172,0.00006372279,0.0006408768,0.00001819711,0.00003058823,0.001940685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.259455,"threshold_uncertainty_score":0.8813494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009355003619116984,"score_gpt":0.2683824820941945,"score_spread":0.2590274784750775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}