{"id":"W4415932855","doi":"10.3390/curroncol32110618","title":"A Multicenter Retrospective Study of Avelumab First-Line Maintenance and Subsequent Therapies for Locally Advanced and Metastatic Urothelial Carcinoma: Subgroup Analysis of First-Line Dose-Dense Methotrexate, Vinblastine, Doxorubicin, and Cisplatin, and Gemcitabine Plus Cisplatin in the Japan AVElumab MAintenance and Continuous Treatment Study (JAVEMACS)","year":2025,"lang":"en","type":"article","venue":"Current Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Merck KGaA; Pfizer","keywords":"Avelumab; Gemcitabine; Retrospective cohort study; Subgroup analysis; Pembrolizumab; Population; Maintenance therapy; Survival analysis; Urothelial carcinoma","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009630476,0.000338934,0.0006296058,0.0007300479,0.0004142778,0.0005401668,0.0003106256,0.0003559713,0.0008448307],"category_scores_gemma":[0.001974478,0.0004129195,0.0009496548,0.001049813,0.0002271146,0.0004091877,0.0003322028,0.0003782158,0.0001715141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005164527,"about_ca_system_score_gemma":0.0004576024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002567472,"about_ca_topic_score_gemma":0.003372473,"domain_scores_codex":[0.998966,0.0002572521,0.0001680109,0.0003374282,0.0001513608,0.0001199975],"domain_scores_gemma":[0.9986218,0.0002346149,0.0005665919,0.0002224991,0.0001382786,0.00021624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001552666,0.00008415939,0.9955013,0.00002134109,0.0002231686,0.0001320009,0.0001130211,0.00002111341,0.0006605749,0.00001525524,0.00009917259,0.001576191],"study_design_scores_gemma":[0.000130156,0.0008112068,0.9967583,0.000008462825,0.000268256,0.0007608775,0.000227891,0.0002297796,0.0002580369,0.00001671526,0.0005219308,0.000008274885],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992589,0.0003389064,0.00005518478,0.000008032199,0.000003365892,0.00001957397,0.0002137872,0.000001662769,0.0001005648],"genre_scores_gemma":[0.9994003,0.00006491887,0.00005508657,0.00001509205,0.000009674694,0.00001695069,0.0003821936,0.000002140194,0.00005374367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002567472,"threshold_uncertainty_score":0.005105078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0459240996353212,"score_gpt":0.363908499100913,"score_spread":0.3179843994655918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}