{"id":"W4415933175","doi":"10.1182/blood.2025030061","title":"PIKfyve inhibition in MM disrupts autophagy and lysosome function, increasing MHC expression and cholesterol metabolism","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Evonik (Canada); Systems, Applications & Products in Data Processing (Canada); Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"National Cancer Institute; National Science Council; Regeneron Pharmaceuticals; Sanofi; Genentech; AstraZeneca; Amgen; Pfizer; Bristol-Myers Squibb; GlaxoSmithKline","keywords":"Autophagy; Downregulation and upregulation; Lysosome; Regulator; Cytotoxicity; Myeloid; Major histocompatibility complex; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001046544,0.0002328455,0.0002556605,0.0001666197,0.0001063749,0.0002430648,0.0001748018,0.0002093812,0.001103733],"category_scores_gemma":[0.00007939807,0.00007969642,0.0002047502,0.0001804771,0.0001524609,0.0001230941,0.0001669129,0.0003759973,0.0002475596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003911626,"about_ca_system_score_gemma":0.0002479739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009594786,"about_ca_topic_score_gemma":0.001437417,"domain_scores_codex":[0.9998932,0.00001182743,0.00001523825,0.00001712505,0.00003193333,0.00003061004],"domain_scores_gemma":[0.9999627,0.000006465543,0.00001100244,0.000005544161,0.000004069011,0.0000102223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002283224,0.00005675736,0.0003092052,0.00002659312,0.000006904992,0.0000301457,0.00000483597,0.00009415472,0.9968812,0.0000824201,0.00007302051,0.00220651],"study_design_scores_gemma":[0.00001264415,0.0002792032,0.001852424,0.000001521256,0.00000619555,0.0000877849,0.000005895812,0.0004056051,0.9962012,0.00001206944,0.001134152,0.000001393105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961611,0.0008124371,0.001015593,0.00007884559,0.00002419854,0.0000237583,0.0005554561,0.00009262193,0.001235937],"genre_scores_gemma":[0.9962981,0.0003952791,0.001218401,0.00004091638,0.000004876309,0.00002100294,0.0004293424,0.000009677889,0.001582371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001103733,"threshold_uncertainty_score":0.003692329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005820190319948074,"score_gpt":0.2500238329173335,"score_spread":0.2442036425973855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}