{"id":"W4415935301","doi":"10.58931/cot.2025.2340","title":"Treatment of dMMR Metastatic Colorectal Cancer in 2025","year":2025,"lang":"","type":"article","venue":"Canadian oncology today.","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Colorectal cancer; Microsatellite instability; DNA mismatch repair; Immune system; Immune checkpoint; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002979534,0.0005947243,0.001857802,0.00167211,0.0001245383,0.00001496705,0.0003567702,0.000677411,0.008948608],"category_scores_gemma":[0.0003672295,0.000603396,0.0002853703,0.001687033,0.0007781226,0.00005092769,0.00005717286,0.0004537868,0.0000861755],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.02192351,"about_ca_system_score_gemma":0.04276146,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.4199803,"about_ca_topic_score_gemma":0.9365275,"domain_scores_codex":[0.9958535,0.0004267086,0.001207606,0.0008633684,0.0002561828,0.001392618],"domain_scores_gemma":[0.9972324,0.0007242142,0.0002788029,0.0005549468,0.0002971816,0.0009124152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002356908,0.001816602,0.4151935,0.0007516824,0.002685111,0.002619279,0.006059779,0.0008728232,0.007522303,0.001425005,0.02050845,0.5381886],"study_design_scores_gemma":[0.01956315,0.01492275,0.3792384,0.001497234,0.003151315,0.00008784435,0.003023587,0.002198105,0.02863649,0.0009054076,0.5457383,0.001037412],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.846516,0.05259046,0.000009723589,0.0124082,0.008054653,0.002756753,0.0007390309,0.00001913031,0.07690606],"genre_scores_gemma":[0.9795209,0.006325254,0.0002790448,0.001165073,0.0001817466,0.000694968,0.00003165831,0.00004683669,0.01175454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5371512,"threshold_uncertainty_score":0.9996417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02695592044157716,"score_gpt":0.3520353368922473,"score_spread":0.3250794164506701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}