{"id":"W4415935301","doi":"10.58931/cot.2025.2340","title":"Treatment of dMMR Metastatic Colorectal Cancer in 2025","year":2025,"lang":"","type":"article","venue":"Canadian oncology today.","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Colorectal cancer; Microsatellite instability; DNA mismatch repair; Immune system; Immune checkpoint; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007393933,0.0001358186,0.0001823351,0.0001890516,0.0001884101,0.0001544598,0.0001275424,0.0002035723,0.002628169],"category_scores_gemma":[0.0001561803,0.0000394383,0.0002221779,0.000204727,0.00008442244,0.00007807745,0.0001151566,0.0002553443,0.0005093623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006133392,"about_ca_system_score_gemma":0.000443563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006622419,"about_ca_topic_score_gemma":0.02661249,"domain_scores_codex":[0.999963,0.00000890129,0.000002677839,0.000004357693,0.000009065036,0.0000119739],"domain_scores_gemma":[0.9999628,0.000004038833,0.000005816263,0.000001638404,0.000005587421,0.00002004072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0094841,0.0009732737,0.03745797,0.001531911,0.0003081757,0.01034988,0.000219188,0.001641117,0.06298822,0.00216457,0.04179576,0.8310859],"study_design_scores_gemma":[0.00258409,0.01833735,0.450478,0.0007030979,0.0004326822,0.03128716,0.0003158808,0.004072338,0.02224453,0.001442325,0.4680463,0.00005635059],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8324319,0.08797593,0.00244049,0.005159794,0.0006766496,0.0003304095,0.001094172,0.0002151591,0.06967546],"genre_scores_gemma":[0.974906,0.01187292,0.001150734,0.001018506,0.0001747382,0.00005000556,0.001021943,0.00001247094,0.009792659],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.006622419,"threshold_uncertainty_score":0.0131678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02695592044157716,"score_gpt":0.3520353368922473,"score_spread":0.3250794164506701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}