{"id":"W4415936435","doi":"10.1021/acsmedchemlett.5c00510","title":"<i>S</i> -Adenosylhomocysteine Analogs Selectively Suppress Pan-Coronavirus Replication by Inhibition of nsp14 Methyltransferase","year":2025,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; Michigan Technology Tri-Corridor; Takeda Canada; Genentech; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Structural Genomics Consortium; Division of Cancer Prevention, National Cancer Institute; Merck KGaA; Genome Canada; National Institute of Allergy and Infectious Diseases; Bayer; Chicago Biomedical Consortium; Bristol-Myers Squibb; Office of Science; Boehringer Ingelheim; U.S. Department of Energy; Pfizer; Janssen Research and Development; Michigan Economic Development Corporation; National Science Foundation","keywords":"Methyltransferase; Docking (animal); Cytotoxicity; Enzyme; Viral replication; Plasma protein binding; Transferase; Coronavirus disease 2019 (COVID-19); Coronavirus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000135321,0.0002199427,0.0002640699,0.0001515934,0.00009842333,0.0001809763,0.0002764972,0.0001870799,0.001400417],"category_scores_gemma":[0.0001329923,0.0001097855,0.0001703269,0.0001150857,0.0001749828,0.0001455623,0.0001470671,0.0004106461,0.0001969135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002100086,"about_ca_system_score_gemma":0.0002214546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004242342,"about_ca_topic_score_gemma":0.001070849,"domain_scores_codex":[0.9999424,0.00001341872,0.000007488724,0.000008292212,0.00001180061,0.00001653068],"domain_scores_gemma":[0.9999481,0.00001070882,0.00001539134,0.000007025137,0.000007897648,0.00001083077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000399216,0.0001150989,0.0002017185,0.00007460402,0.00001752058,0.00009961324,0.00001732657,0.0006690182,0.9920486,0.0002575866,0.0001395686,0.0059602],"study_design_scores_gemma":[0.0001269264,0.002121784,0.0007796898,0.000006519331,0.00001923067,0.0001742617,0.00001566563,0.001111963,0.9926249,0.00008999222,0.002922949,0.000005980512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924036,0.001336193,0.002207376,0.0001283935,0.00003496005,0.00009939264,0.0002660121,0.0000958294,0.003428203],"genre_scores_gemma":[0.9947991,0.000875664,0.002661098,0.00008129796,0.00001223447,0.00004329102,0.0002629177,0.00001341879,0.001250904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001400417,"threshold_uncertainty_score":0.004684865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009360647879220184,"score_gpt":0.2719855091314359,"score_spread":0.2626248612522157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}