{"id":"W4415937993","doi":"10.1056/evidoa2500155","title":"Targeted Oral Peptide Icotrokinra for Psoriasis Involving High-Impact Sites","year":2025,"lang":"en","type":"article","venue":"NEJM Evidence","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lynde Centre for Dermatology; University of Toronto; Probity Medical Research; Innovaderm (Canada); SKiN Health","funders":"","keywords":"Psoriasis; Placebo; Scalp; Peptide; Adverse effect; Oral cavity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003228748,0.0002957606,0.0004392561,0.0002041409,0.0003356884,0.000047772,0.0003532832,0.0002821144,0.000485784],"category_scores_gemma":[0.0008034781,0.0002451668,0.0002763882,0.0003625565,0.0001056997,0.0003084675,0.00009395918,0.0001486003,0.0003185818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001387326,"about_ca_system_score_gemma":0.0001668139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003824078,"about_ca_topic_score_gemma":0.0001459898,"domain_scores_codex":[0.9984173,0.0002030625,0.0003271726,0.0004769233,0.00004564272,0.0005299466],"domain_scores_gemma":[0.998179,0.001087955,0.0001236693,0.0004268094,0.0001485015,0.0000340899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001305181,0.0001981862,0.09555423,0.0001207308,0.001190425,0.000009908136,0.0004344287,0.00003891498,0.7797251,0.002581599,0.05716649,0.06167476],"study_design_scores_gemma":[0.005947601,0.001128026,0.3417384,0.0009784304,0.001437621,0.0000244249,0.0003253918,0.00007242053,0.6065679,0.003952287,0.03685041,0.0009771738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683734,0.02743799,0.0008307782,0.0006558071,0.001603446,0.0005750802,0.0001102758,0.0001916612,0.0002215171],"genre_scores_gemma":[0.990079,0.0006371326,0.001191919,0.0003112791,0.0000913746,0.0001682645,0.0001732323,0.0000204218,0.007327401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2461841,"threshold_uncertainty_score":0.9997611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03823424837231556,"score_gpt":0.3068054505454589,"score_spread":0.2685712021731434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}