{"id":"W4415937993","doi":"10.1056/evidoa2500155","title":"Targeted Oral Peptide Icotrokinra for Psoriasis Involving High-Impact Sites","year":2025,"lang":"en","type":"article","venue":"NEJM Evidence","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lynde Centre for Dermatology; University of Toronto; Probity Medical Research; Innovaderm (Canada); SKiN Health","funders":"","keywords":"Psoriasis; Placebo; Scalp; Peptide; Adverse effect; Oral cavity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007264858,0.0004033973,0.001029783,0.0002142903,0.0001615504,0.0003403773,0.000331933,0.0006050795,0.004237211],"category_scores_gemma":[0.0005762763,0.0001877772,0.000406434,0.0002355869,0.0004193416,0.0002792991,0.0001821445,0.0009262661,0.0004571762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001531164,"about_ca_system_score_gemma":0.000468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002405922,"about_ca_topic_score_gemma":0.0005317774,"domain_scores_codex":[0.9998387,0.00006525678,0.00001827361,0.00002990849,0.00002637311,0.00002149362],"domain_scores_gemma":[0.9996949,0.0001069611,0.00009004064,0.00001412391,0.00001826335,0.00007572209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6250741,0.01151432,0.003288147,0.008310545,0.001173292,0.0004188618,0.0001512456,0.001294105,0.08054405,0.0005064816,0.002777385,0.2649474],"study_design_scores_gemma":[0.7400128,0.2383573,0.006112877,0.0004425992,0.000803324,0.001013245,0.00008270252,0.0006790221,0.007758525,0.0002076411,0.00450532,0.00002460667],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687392,0.02545286,0.001077107,0.00027675,0.000241142,0.001865825,0.0002515163,0.00006970057,0.002025875],"genre_scores_gemma":[0.9790684,0.01458357,0.00205038,0.0004539298,0.0002791567,0.001707021,0.0002730763,0.000009994164,0.001574415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004237211,"threshold_uncertainty_score":0.01417488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03823424837231556,"score_gpt":0.3068054505454589,"score_spread":0.2685712021731434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}