{"id":"W4415939788","doi":"10.1016/j.annonc.2025.08.3072","title":"2457P CDK12 as a prostate cancer predisposition gene","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; Queen's University; University of British Columbia","funders":"Canadian Cancer Society; Michael Smith Health Research BC; Prostate Cancer Canada; AstraZeneca; BC Cancer Foundation; Prostate Cancer Foundation","keywords":"Prostate cancer; Gene; Genetic predisposition; Cancer; Prostate","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001126376,0.0005008288,0.0002819954,0.001403556,0.0006911228,0.0006362522,0.0004837416,0.001127626,0.008983649],"category_scores_gemma":[0.0005595669,0.0002156677,0.0003841273,0.0008467707,0.0003531658,0.0001652141,0.0003523979,0.000688843,0.001154166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004447987,"about_ca_system_score_gemma":0.0004834383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00282765,"about_ca_topic_score_gemma":0.002649678,"domain_scores_codex":[0.9998446,0.00002693602,0.00001056334,0.00003937566,0.00004573763,0.00003276736],"domain_scores_gemma":[0.999712,0.00007564616,0.00006649983,0.00001458728,0.00003253473,0.00009860429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.003085943,0.0003628208,0.1764791,0.0006377159,0.0006237883,0.3782589,0.0006289473,0.001911898,0.2941398,0.01418845,0.01608635,0.1135961],"study_design_scores_gemma":[0.0003126613,0.0004654856,0.2677701,0.0002613197,0.001189222,0.4943795,0.000847374,0.005191186,0.1048879,0.007742199,0.1168432,0.0001098374],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9453351,0.009155121,0.004096739,0.005026448,0.0008746455,0.00009332208,0.002398509,0.0004358476,0.03258433],"genre_scores_gemma":[0.9899015,0.001199577,0.001169684,0.0004033341,0.0001644266,0.00001091089,0.0005040864,0.000048758,0.006597656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008983649,"threshold_uncertainty_score":0.03005326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03465988076334953,"score_gpt":0.4007685728006128,"score_spread":0.3661086920372633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}