{"id":"W4415939936","doi":"10.1016/j.annonc.2025.08.3355","title":"2745eP Isocitrate dehydrogenase 1 (IDH1) mutation testing in the phase III study of ivosidenib vs placebo in IDH1-mutant conventional chondrosarcoma (CHONQUER)","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Bone Tumor Diagnosis and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Servier","keywords":"Isocitrate dehydrogenase; Chondrosarcoma; IDH1; Placebo; Phases of clinical research; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007342114,0.001062677,0.001801933,0.0002698697,0.000260771,0.0007921472,0.0007553639,0.0009811817,0.003956771],"category_scores_gemma":[0.0007050353,0.000340736,0.001086244,0.0002628203,0.0006312786,0.000440596,0.0001968848,0.00221611,0.0006632215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007652161,"about_ca_system_score_gemma":0.0009618849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002598288,"about_ca_topic_score_gemma":0.007906517,"domain_scores_codex":[0.9997239,0.0001259536,0.00001043744,0.00004022565,0.00002135065,0.00007810845],"domain_scores_gemma":[0.9996692,0.0000861099,0.00004675062,0.00002206158,0.00002783031,0.0001480093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8854529,0.01070294,0.003022981,0.0006763001,0.001844984,0.0001423263,0.00009615174,0.0009948119,0.0178825,0.0003964907,0.003119317,0.07566834],"study_design_scores_gemma":[0.8093489,0.1752767,0.0085311,0.0000650526,0.0009708532,0.0001746747,0.00009977915,0.0008031232,0.002437213,0.0002736261,0.001991583,0.0000272677],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991719,0.003466642,0.0002695907,0.0005364171,0.0002413307,0.0005432595,0.0005486609,0.00008209666,0.002593078],"genre_scores_gemma":[0.9922077,0.002265578,0.0005088644,0.0005596206,0.0001716334,0.000439283,0.000910108,0.0000224392,0.002914811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003956771,"threshold_uncertainty_score":0.0132367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09453919579035619,"score_gpt":0.4260114084928522,"score_spread":0.331472212702496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}