{"id":"W4415940698","doi":"10.1016/j.annonc.2025.08.2791","title":"2172P Pathological complete response in gastroesophageal cancer trials: A reliable surrogate for overall survival?","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; BC Cancer Agency","funders":"","keywords":"Complete response; Pathological; Cancer; Surrogate endpoint; Drug response","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.05653659,0.001359301,0.006217853,0.0008502456,0.0005877141,0.003838831,0.001492217,0.002845325,0.003774807],"category_scores_gemma":[0.0518969,0.0007578542,0.004063037,0.001745885,0.001436439,0.003971298,0.00139382,0.005953315,0.001586161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001210511,"about_ca_system_score_gemma":0.001592702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003943148,"about_ca_topic_score_gemma":0.001145876,"domain_scores_codex":[0.9493945,0.04352469,0.002674541,0.001551561,0.001979245,0.0008753503],"domain_scores_gemma":[0.9698325,0.01845682,0.005976785,0.003006922,0.001688573,0.001038429],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.3531987,0.001375507,0.1003964,0.01120237,0.04013935,0.0005685003,0.000716547,0.0125204,0.003411306,0.01287267,0.06915613,0.3944422],"study_design_scores_gemma":[0.2147601,0.1326788,0.2456681,0.008476304,0.04811622,0.002165951,0.001267893,0.03862705,0.008144826,0.05959095,0.2397268,0.0007770646],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5882187,0.2209528,0.03298714,0.06658732,0.01425883,0.004000561,0.01872871,0.001035488,0.05323039],"genre_scores_gemma":[0.9493585,0.009434381,0.008854982,0.01334562,0.003491948,0.004091331,0.005946964,0.0002588565,0.005217417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9434634,"threshold_uncertainty_score":0.2989976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2830464592434614,"score_gpt":0.5156410703034147,"score_spread":0.2325946110599533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}