{"id":"W4415940700","doi":"10.1016/j.annonc.2025.08.2608","title":"1984P Real-world efficacy and outcomes in older adults with advanced anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC): A Canadian multicenter experience","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Brampton Civic Hospital; Queen Elizabeth II Health Sciences Centre; Hôpital du Sacré-Cœur de Montréal; McGill University; BC Cancer Agency; Northeast Cancer Centre; Institute of Cancer Research; Juravinski Cancer Centre; Western University; University Health Network; Ottawa Regional Cancer Foundation; Hôpital Fleurimont; Princess Margaret Cancer Centre","funders":"","keywords":"Lung cancer; Anaplastic lymphoma kinase; Clinical trial; Lymphoma; MEDLINE; Multicenter study","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002625973,0.0005450282,0.0007774323,0.0005261094,0.001584042,0.00120531,0.0006674824,0.0006872451,0.001473766],"category_scores_gemma":[0.00362497,0.0001857007,0.0009626238,0.001953052,0.0007825681,0.0006487469,0.0006868322,0.0008610347,0.0002822622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01673315,"about_ca_system_score_gemma":0.01564686,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.7248185,"about_ca_topic_score_gemma":0.8083714,"domain_scores_codex":[0.9988946,0.0002019412,0.00005879011,0.0001411581,0.0003864906,0.000317006],"domain_scores_gemma":[0.9968064,0.0003518292,0.0005811882,0.0001025079,0.001108097,0.001050001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01192256,0.002018193,0.9312758,0.0002213091,0.0008062836,0.0002988589,0.001281797,0.0007811937,0.001016621,0.000293526,0.008920466,0.04116348],"study_design_scores_gemma":[0.00139698,0.002661462,0.989861,0.00008105757,0.0003369451,0.0001393674,0.0006934766,0.000281422,0.0001738781,0.00007255194,0.004259895,0.00004185095],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895791,0.001256982,0.00009410947,0.0006730337,0.00003433056,0.0002607278,0.004760175,0.000007382775,0.003334058],"genre_scores_gemma":[0.9921138,0.001138355,0.0003488419,0.0005494216,0.00006625928,0.0001859628,0.004727468,0.000008273209,0.0008615815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2751815,"threshold_uncertainty_score":0.5536041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01390695631390433,"score_gpt":0.3705956109970542,"score_spread":0.3566886546831499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}