{"id":"W4415941094","doi":"10.1016/j.annonc.2025.08.1524","title":"955P Updated clinical results of BT-001, an oncolytic virus expressing an anti-CTLA4 mAb, administered in combination with pembrolizumab in patients with advanced solid tumors","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Barbara Ann Karmanos Cancer Institute; Institut Gustave-Roussy; McGill University Health Centre; McGill University; Boehringer Ingelheim; Institut National Du Cancer; Wayne State University; Case Western Reserve University; Cleveland Clinic; University of Texas MD Anderson Cancer Center; Pfizer; Bristol-Myers Squibb","keywords":"Oncolytic virus; Pembrolizumab; Virus; Vaccinia; Immunotherapy; Solid tumor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001492699,0.0006092983,0.001120865,0.000939523,0.0002840469,0.00136652,0.0006802006,0.000851601,0.00468465],"category_scores_gemma":[0.002092743,0.0001964627,0.000864881,0.001188124,0.0002111176,0.0005967538,0.0002967151,0.001303596,0.001364517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001529553,"about_ca_system_score_gemma":0.0009686194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003056536,"about_ca_topic_score_gemma":0.00578434,"domain_scores_codex":[0.9994469,0.0001339481,0.00006798613,0.00004840481,0.0002492259,0.00005341873],"domain_scores_gemma":[0.9989306,0.0002783253,0.0002019304,0.00004635067,0.0004141976,0.000128559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01674279,0.0007323684,0.01534505,0.002426011,0.001528676,0.001554621,0.00009060216,0.001650622,0.01343525,0.0008641349,0.1819085,0.7637214],"study_design_scores_gemma":[0.005137668,0.007810022,0.1158808,0.0007434405,0.005315398,0.003921729,0.00007918778,0.001780921,0.014764,0.0008902847,0.8435996,0.00007695102],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2568189,0.3957127,0.008740232,0.04310711,0.01362702,0.001434304,0.0796884,0.001805206,0.1990662],"genre_scores_gemma":[0.6867429,0.1250463,0.01100404,0.02956094,0.008888553,0.001176268,0.08752479,0.0005153202,0.04954085],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00468465,"threshold_uncertainty_score":0.01567173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04949690723705114,"score_gpt":0.4242128900780724,"score_spread":0.3747159828410213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}