{"id":"W4415941336","doi":"10.1016/j.annonc.2025.08.1892","title":"1258P ULBP2 drives a non-canonical NK cell cytotoxicity in B-ALL: A novel mechanism associated with improved patient survival","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; National Research Council Canada; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Research Council Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Cytotoxicity; Immunotherapy; Cytotoxic T cell; Mechanism (biology); Leukemia; Cell; Cell survival; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001426533,0.0002238667,0.0002324813,0.0001621696,0.0002009132,0.0005643844,0.0002510429,0.0003247391,0.003134509],"category_scores_gemma":[0.0001837423,0.0001231703,0.0002103567,0.0001282451,0.0002590283,0.0001848954,0.0003240547,0.0007847878,0.0006917492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004089091,"about_ca_system_score_gemma":0.0001929503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003292048,"about_ca_topic_score_gemma":0.0004217644,"domain_scores_codex":[0.9998335,0.00002435496,0.00001389807,0.0000375233,0.00003990264,0.00005074549],"domain_scores_gemma":[0.9999204,0.00001106576,0.00002081977,0.00001562705,0.000006993191,0.00002508103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004056511,0.00008068744,0.001776681,0.00003836271,0.00001359731,0.0003670669,0.00001975029,0.0001272718,0.9916618,0.0005264473,0.0003741785,0.004608668],"study_design_scores_gemma":[0.0002393609,0.001556575,0.05335519,0.00001821365,0.000112209,0.006973383,0.000194731,0.004553044,0.9157829,0.0008408261,0.01635218,0.00002130267],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936956,0.0008685853,0.001987597,0.0002506488,0.00006371998,0.00002538234,0.0002811267,0.0001472811,0.002680077],"genre_scores_gemma":[0.9982044,0.00009905409,0.0003069286,0.00005817533,0.000009583103,0.00001010157,0.000174612,0.00001423841,0.001122832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003134509,"threshold_uncertainty_score":0.01048601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03421493878852729,"score_gpt":0.3039542507682866,"score_spread":0.2697393119797593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}