{"id":"W4415941497","doi":"10.1016/j.annonc.2025.08.2714","title":"3208P 10-year outcomes from clinical trials of pembrolizumab (pembro) monotherapy for locally advanced or metastatic non-small cell lung cancer (NSCLC)","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Merck Sharp and Dohme","keywords":"Pembrolizumab; Clinical trial; Lung cancer; Immunotherapy; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003827488,0.0008015083,0.001827823,0.000412237,0.0003186687,0.001144715,0.0006241627,0.001278382,0.003314832],"category_scores_gemma":[0.003863817,0.0003362489,0.003699034,0.0005096394,0.000499477,0.001768391,0.0007640662,0.002014229,0.0006478223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009409851,"about_ca_system_score_gemma":0.0006415182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009578756,"about_ca_topic_score_gemma":0.001694496,"domain_scores_codex":[0.9980794,0.0009048565,0.0001879488,0.0003565941,0.0002202676,0.0002508972],"domain_scores_gemma":[0.9976513,0.000838652,0.0007717879,0.0001944062,0.0001763437,0.0003675658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7954973,0.002283918,0.05996293,0.00235901,0.02164983,0.0002699898,0.0001734268,0.003682838,0.006119558,0.0004641713,0.01089301,0.09664402],"study_design_scores_gemma":[0.239954,0.1652433,0.5346785,0.0007554381,0.0305541,0.0009261813,0.0003017407,0.003984989,0.003209957,0.002049744,0.01818563,0.0001564254],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9716364,0.0134778,0.0004772706,0.001181388,0.0002761864,0.0003011236,0.008302468,0.00004775995,0.004299685],"genre_scores_gemma":[0.9875706,0.002375431,0.0002310366,0.0005675839,0.0001810954,0.0003533332,0.006808961,0.00001779974,0.001894248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003827488,"threshold_uncertainty_score":0.02024192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1931341022782583,"score_gpt":0.51311728074028,"score_spread":0.3199831784620217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}