{"id":"W4415941756","doi":"10.1016/j.annonc.2025.08.2362","title":"1734TiP CELEBRATE study (JCOG2107E): A multicenter, open-label, phase III trial of etoposide, carboplatin, and durvalumab in first-line treatment of unresectable or recurrent digestive NEC","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Winship Cancer Institute; Novartis Pharma; Deutschen Konsortium für Translationale Krebsforschung; Fundació Institut de Recerca Hospital Universitari Vall d’Hebron; Novartis Institutes for BioMedical Research; Universität Duisburg-Essen; Emory University; University of Toronto; Yale University; AstraZeneca","keywords":"Durvalumab; Phases of clinical research; Clinical trial; Digestive tract","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001232363,0.001159875,0.001890301,0.0003074501,0.0003920987,0.001155427,0.0009963494,0.0009658125,0.006451732],"category_scores_gemma":[0.0007928571,0.0003977394,0.001220699,0.0003266123,0.0008509495,0.0008393351,0.000412755,0.003740564,0.001250549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000755145,"about_ca_system_score_gemma":0.00124891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009944997,"about_ca_topic_score_gemma":0.004542125,"domain_scores_codex":[0.9997545,0.0001110553,0.000008644478,0.00004299844,0.00002417325,0.00005852821],"domain_scores_gemma":[0.9995695,0.00006338482,0.00006596406,0.0000374727,0.00002440808,0.0002391694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7827633,0.02867273,0.006486723,0.001485389,0.003439304,0.0002832549,0.0001918391,0.001797735,0.02039621,0.0009234923,0.02076981,0.1327902],"study_design_scores_gemma":[0.8748311,0.1075647,0.007818508,0.00005833257,0.0008730344,0.0002367307,0.00007348347,0.000963427,0.001824089,0.0002907919,0.005428795,0.00003705985],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836327,0.003730092,0.0006361681,0.001414868,0.0005604192,0.001402482,0.00340699,0.0002397586,0.004976495],"genre_scores_gemma":[0.9703321,0.003706566,0.002889053,0.003345871,0.0005776547,0.00177931,0.008061664,0.00009631113,0.009211482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006451732,"threshold_uncertainty_score":0.0215832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1562346096926946,"score_gpt":0.4693949005740966,"score_spread":0.313160290881402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}