{"id":"W4415942202","doi":"10.1016/j.annonc.2025.08.2840","title":"2223P First-line (1L) AZD0171 + durvalumab (D) + chemotherapy (CT) in patients (pts) with metastatic pancreatic ductal adenocarcinoma (mPDAC): Phase II study results","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Royal Victoria Regional Health Centre","funders":"AstraZeneca","keywords":"Chemotherapy; Durvalumab; Pancreatic ductal adenocarcinoma; Phases of clinical research; Gemcitabine; Adenocarcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005989242,0.0009131213,0.001448978,0.0002818035,0.000212371,0.0007485232,0.0005687629,0.0004952486,0.002944736],"category_scores_gemma":[0.0004233856,0.0003016189,0.0008696819,0.0003505925,0.0003957006,0.000469142,0.00020847,0.001801733,0.0007882433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009242086,"about_ca_system_score_gemma":0.001066141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002089273,"about_ca_topic_score_gemma":0.006789871,"domain_scores_codex":[0.999831,0.00006878897,0.000007938644,0.00003247957,0.00001855814,0.00004116698],"domain_scores_gemma":[0.9997924,0.00003097773,0.00003461152,0.00001679868,0.00001211045,0.0001130729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4382086,0.03973072,0.01811236,0.001729053,0.003498883,0.0004475485,0.0002914157,0.005805315,0.07551236,0.000585057,0.01239337,0.4036853],"study_design_scores_gemma":[0.4992175,0.4211458,0.0436974,0.0001376174,0.002309568,0.001386412,0.0001530103,0.003415101,0.01332736,0.0004190294,0.01472706,0.00006416708],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888002,0.004599446,0.0004904012,0.0004581295,0.0001266302,0.000642388,0.001995288,0.0001151638,0.002772394],"genre_scores_gemma":[0.9826956,0.005759415,0.001610069,0.0006363001,0.0001174353,0.0006372741,0.004653182,0.00005156884,0.003839212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002944736,"threshold_uncertainty_score":0.009851158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07829122726750101,"score_gpt":0.4275496093810707,"score_spread":0.3492583821135697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}