{"id":"W4415942231","doi":"10.1016/j.annonc.2025.08.3305","title":"2694P Long-term efficacy and safety of vimseltinib in patients (pts) with tenosynovial giant cell tumor (TGCT): 2-year results from the MOTION phase III trial","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Musculoskeletal synovial abnormalities and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Placebo; Clinical trial; Phases of clinical research; Disease; Circulating tumor cell; Neoplasm","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006741076,0.0009269189,0.00148403,0.0001917276,0.0002894847,0.000887626,0.0004866048,0.0008611759,0.003211719],"category_scores_gemma":[0.0007169467,0.000257038,0.001444571,0.0002643621,0.0004742621,0.00071069,0.000245593,0.002021781,0.0009137522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000713878,"about_ca_system_score_gemma":0.0006771106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008563579,"about_ca_topic_score_gemma":0.002239926,"domain_scores_codex":[0.9998077,0.00006267732,0.00001299969,0.00003190723,0.00002217456,0.00006259189],"domain_scores_gemma":[0.9997172,0.00005627002,0.0000777328,0.00001613324,0.00002517351,0.0001075046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7297754,0.005890707,0.01159799,0.001948468,0.003717762,0.0004372539,0.0001708728,0.004547643,0.02389099,0.0007040571,0.01178672,0.2055321],"study_design_scores_gemma":[0.7276413,0.2089123,0.04276071,0.0002480755,0.002704643,0.0009446512,0.000183339,0.003565787,0.004248381,0.0008077784,0.007894283,0.00008890166],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899908,0.005051878,0.0002390037,0.0006884189,0.0001785956,0.0002855659,0.001319582,0.00009223311,0.002153897],"genre_scores_gemma":[0.9920951,0.00213662,0.0003047707,0.0005557683,0.0001202722,0.0002831033,0.002123142,0.0000164115,0.002364838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003211719,"threshold_uncertainty_score":0.01074421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02796030462185842,"score_gpt":0.3379943246076695,"score_spread":0.310034019985811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}