{"id":"W4415942648","doi":"10.1016/j.annonc.2025.08.912","title":"489MO Patient-reported outcomes (PROs) with vepdegestrant (VEP) vs fulvestrant (FUL) in patients (pts) with estrogen receptor (ER) 1 gene mutated (ESR1m) ER+/human epidermal growth factor receptor 2 (HER2) : Advanced breast cancer (aBC) in the phase 3 VERITAC-2 trial","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Fulvestrant; Estrogen receptor; Breast cancer; Clinical trial; Gene; Epidermal growth factor receptor; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006928922,0.0006288646,0.0008627246,0.0001635149,0.0001416567,0.0006043032,0.0002508285,0.0005634546,0.004974045],"category_scores_gemma":[0.0006738549,0.0001552415,0.001625767,0.0002109999,0.0002363318,0.0005233453,0.0002333044,0.001426562,0.0005124921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003488875,"about_ca_system_score_gemma":0.0002456736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003275843,"about_ca_topic_score_gemma":0.0008720488,"domain_scores_codex":[0.9997811,0.0001030511,0.00001312844,0.00002951265,0.00002316146,0.00005009826],"domain_scores_gemma":[0.9997292,0.00009561632,0.00007851192,0.00001484687,0.0000100848,0.00007158893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.874406,0.001819738,0.00986918,0.0008322631,0.003538353,0.0001637002,0.00005010135,0.00475875,0.008136628,0.0004953053,0.004050284,0.09187961],"study_design_scores_gemma":[0.4694749,0.3131386,0.1709319,0.0004258819,0.009692439,0.001204159,0.0002457539,0.009907538,0.008079906,0.002949404,0.01380885,0.0001407352],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870466,0.005790943,0.00046259,0.0005058555,0.0002112382,0.0001570805,0.00268701,0.00007511703,0.003063674],"genre_scores_gemma":[0.9929622,0.001546552,0.0002121026,0.0004507536,0.0001101094,0.0002175895,0.002592355,0.00001100711,0.001897309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004974045,"threshold_uncertainty_score":0.01663983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0215413814384618,"score_gpt":0.32627467992751,"score_spread":0.3047332984890482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}