{"id":"W4415942707","doi":"10.1016/j.annonc.2025.08.3007","title":"2391P LuPARP: Phase I trial of [177Lu]Lu-PSMA-617 (LuPSMA) and olaparib in patients (pts) with metastatic castration resistant prostate cancer (mCRPC)","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Olaparib; Radiosensitizer; Prostate cancer; Radiation therapy; PARP inhibitor; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007281632,0.001444564,0.001746311,0.0003999925,0.0003752155,0.001525009,0.0009359872,0.001262554,0.008479901],"category_scores_gemma":[0.0007042274,0.0005860137,0.001331829,0.0005034807,0.0007422221,0.0008739154,0.0004913164,0.003542965,0.002289378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009768673,"about_ca_system_score_gemma":0.001475405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001369934,"about_ca_topic_score_gemma":0.003091315,"domain_scores_codex":[0.9997103,0.0001138945,0.00001123738,0.00005279982,0.00002318576,0.00008856433],"domain_scores_gemma":[0.9996784,0.00004030192,0.00004534933,0.00002152398,0.00001287549,0.0002015973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7985898,0.01404591,0.002721411,0.001075612,0.001561145,0.0003448445,0.0001615078,0.003475606,0.02779419,0.0008980784,0.01241457,0.1369172],"study_design_scores_gemma":[0.8011915,0.1760996,0.006384673,0.00007932328,0.000766178,0.0005613269,0.00007312315,0.002000008,0.003852853,0.0007560708,0.008168419,0.00006695966],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750721,0.005913851,0.0007842934,0.001906902,0.0004897902,0.002097056,0.004250363,0.0005894164,0.008896269],"genre_scores_gemma":[0.9771909,0.003753636,0.00163996,0.001430247,0.0003223695,0.00140576,0.005989305,0.00009309562,0.008174765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008479901,"threshold_uncertainty_score":0.02836806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08780623247322457,"score_gpt":0.4548348839518723,"score_spread":0.3670286514786477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}