{"id":"W4415942737","doi":"10.1016/j.ekir.2025.10.028","title":"Delphi Consensus on Surrogate End Points in C3 Glomerulopathy and Primary Immune Complex–Mediated Membranoproliferative Glomerulonephritis","year":2025,"lang":"en","type":"article","venue":"Kidney International Reports","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Swedish Orphan Biovitrum","keywords":"Membranoproliferative glomerulonephritis; Glomerulopathy; Proteinuria; End point; Immune system; Glomerulonephritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004904824,0.0002683679,0.0004657566,0.000457652,0.0001244443,0.00004033672,0.0001772384,0.0001384747,0.001411623],"category_scores_gemma":[0.001620843,0.000273219,0.00009432761,0.0002093581,0.0002497114,0.00007637261,0.0002170084,0.0002410085,0.00009164079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002347543,"about_ca_system_score_gemma":0.0003306877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003722116,"about_ca_topic_score_gemma":0.00008100774,"domain_scores_codex":[0.9977277,0.0002539445,0.0009743702,0.0005658825,0.000152051,0.0003260462],"domain_scores_gemma":[0.9985607,0.0004752178,0.0003500327,0.0003353238,0.0002057351,0.00007300876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002226446,0.001538997,0.3949324,0.0003745695,0.002154767,0.003245136,0.001090795,0.000018336,0.4792881,0.009712756,0.09941861,0.005999105],"study_design_scores_gemma":[0.007052447,0.0001872635,0.8111727,0.001329501,0.00008521802,0.001706973,0.0003868864,0.00005027134,0.0245021,0.003069675,0.1498058,0.0006512146],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9634215,0.001620056,0.00001150743,0.006960831,0.002563753,0.0007674955,0.0006976941,0.0001097983,0.02384739],"genre_scores_gemma":[0.9935644,0.00009083042,0.0000719638,0.00223375,0.00002741653,0.0001050478,0.002068829,0.00001614037,0.001821602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.454786,"threshold_uncertainty_score":0.999972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01126706764885216,"score_gpt":0.2650360612333723,"score_spread":0.2537689935845202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}