{"id":"W4415947693","doi":"10.1136/gutjnl-2025-336180","title":"Indole-3-propionic acid links gut dysfunction to diabetic retinopathy: a biomarker and novel therapeutic approach","year":2025,"lang":"en","type":"article","venue":"Gut","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute","funders":"National Eye Institute; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Research to Prevent Blindness","keywords":"Biomarker; Therapeutic approach; Diabetes mellitus; Nutraceutical; Biomarker discovery; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000127551,0.0001557609,0.0001370036,0.0000780524,0.00008781084,0.00003208954,0.0001078266,0.000230013,0.000007486507],"category_scores_gemma":[0.00003651275,0.0001364902,0.00004931082,0.0001716413,0.00005474393,0.000003397405,0.0001439029,0.0001278256,0.00001434815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001492794,"about_ca_system_score_gemma":0.00007146726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001024163,"about_ca_topic_score_gemma":0.000003676141,"domain_scores_codex":[0.9991055,0.00003243551,0.000157875,0.0003992044,0.00008129069,0.0002236989],"domain_scores_gemma":[0.9995225,0.000006180003,0.00003742551,0.0003133955,0.0000507588,0.00006970931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009459781,0.00008835956,0.001374945,0.00004538098,0.00009466871,0.00000116116,0.00002962597,0.000004880917,0.9792523,0.0003860758,0.0005412716,0.01808672],"study_design_scores_gemma":[0.004075644,0.0008451645,0.113919,0.0001377588,0.0002748378,0.00009447675,0.0002955915,0.0008699964,0.752471,0.0009851897,0.1250501,0.0009812771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752191,0.002643254,0.01721727,0.0007470451,0.0002467405,0.0003725331,0.0000151152,0.00002534499,0.003513652],"genre_scores_gemma":[0.9963557,0.000107602,0.0006599699,0.001000076,0.0001243174,0.00006307376,0.0001096746,0.00001672011,0.00156287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2267814,"threshold_uncertainty_score":0.556591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01290632725057943,"score_gpt":0.2489253826804077,"score_spread":0.2360190554298283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}